The aim of this study is to investigate the efficacy of CGF and Ozone in the treatment of alveolitis and to develop a new treatment protocol that can enable a quick and effective solution of this clinical problem, which significantly affects patients' comfort of life.

In the present study, 60 healthy patients > 18 years old and have alveolitis, will included. 60 patient will divided randomly into three groups as Control, Ozone and Ozone+CGF. After irrigation of the sockets alvogyl, ozone and ozone+CGF will applied to the sockets respectively. Post operative pain, will measured at 1st to 7th days. Post operative infection, and granulation tissue will measured at 1st, 3rd and 7th days. Oral hygiene will evaluated at first visit. Quality of life will evaluated at 7th day.

Inclusion Criteria:

Patients who have one or more of the following in addition to severe pain, which occur within and around the socket 1-3 days after extraction and do not decrease with pain killers;

• With a partially or completely disintegrated blood clot in the socket
• With exposed bone that gives a dark gray appearance
• With bad odor

Exclusion Criteria:

• Who does not want to be volunteer for the study,
• Smokers,
• During pregnancy or lactation,
• Has a chronic systemic disorder that will affect recovery,
• Has hematological disorder
• Cooperation cannot be established,
• Previously received radiotherapy or chemotherapy,
• Patients using oral contraceptives

IPD can share with other researchers on demand