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| ID | Type | Description | Link |
|---|---|---|---|
| COV20/00181 | Other Grant/Funding Number | Instituto de Salud Carlos III |
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| Name | Class |
|---|---|
| Hospital Universitario 12 de Octubre | OTHER |
| Fundacion Investigacion Biomedica Hospital 12 de Octubre | UNKNOWN |
| Hospital Universitario Fundación Jiménez Díaz | OTHER |
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The STOP-Coronavirus project is an integrated and multidisciplinary study that aims to analyze the impact that various factors have on the evolution and prognosis of the current COVID-19. Clinical presentation, immunological markers, therapeutic strategies, host and virus genomics, and bioethical considerations will be analyzed with a prospective multicenter cohort of patients with a diagnosis of COVID-19.
This project led my Dr Aguado Garcia, has established 8 Work Parckages (WP) to analyze factors involved in the impact of COVID-19. WP that correspond to University Hospital Fundacion Jimenez Diaz are described in this register across different objectives:
WP 3 (Dr Ayuso García) is aimed to analyze the genetic markers of host susceptibility associated with clinical evolution of COVID-19.
WP 6 (Dr Ruiz Hornillos) will study the socio-economic and bioethical repercussions of COVID-19.
WP 7 (Dr Perales) will analyze the complexity of the spectrum of SARS-CoV-2 mutants and their possible association with the evolutionary course of COVID-19
This project will guide and individualize the clinical and therapeutic approach to COVID-19 and mitigate the health and social impact of the pandemic.
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| Measure | Description | Time Frame |
|---|---|---|
| Identification of host genetic markers associated with the evolution of COVID-19 | Based on the cohort of patients with a confirmed diagnosis of COVID-19 and according to severity categories, a Genome-wide association study (GWAS) will be carried out | 4 months |
| Analysis of bioethical aspects related to in-hospital management of the health crisis | Through structured interviews, data collection in each epidemiological period, and evaluation of the application of recommended measures from the bioethical point of view, a comparative study will be carried out between hospitals, taking into account the use of resources and analyzing the situations of ethical commitment for healthcare professionals, patients and institutions | 10 months |
| Analysis of the spectrum of mutants of SARS-CoV-2 and its possible association with the clinical evolution of COVID-19 | From the mass sequencing of SARS-CoV-2 and the calculation of viral variability indices, it will be studied whether or not there is an association between the spectrum of viral mutants and clinical evolution | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with confirmed diagnosis of COVID-19 (positive RT-PCR for SARS-CoV-2 in respiratory sample) will from the following university hospitals, will be enrolled for the study:
Hospital Universitario 12 de Octubre, Hospital Universitario Fundación Jiménez Díaz, Hospital Universitario Infanta Elena, Hospital Clínico Universtario Virgen de la Arrixaca
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fundacion Jimenez Diaz | Madrid | 28040 | Spain |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Hospital Universitario Infanta Elena |
| UNKNOWN |
| Hospital Universitario Virgen de la Arrixaca | OTHER |
| Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca | OTHER |
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SARS-CoV-2
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |