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The study was designed to compare the acute effects of left bundle branch pacing (LBBP) with biventricular pacing (BVP) in patients with left ventricular ejection fraction (LVEF) <=35% with left bundle branch block (LBBB).
The metrics include electrocardiographic, echocardiographic and hemodynamic parameters to evaluate and compare LBBP with BVP for resynchronization therapy in patients with heart failure and LBBB.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Left bundle branch pacing | Experimental | Left bundle branch pacing |
|
| Biventricular pacing | Active Comparator | Biventricular pacing |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| left bundle branch pacing | Procedure | left bundle branch pacing |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic parameter LV dP/dt(max) | LV dP/dt(max) will be obtained during implant procedure. | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Electrical synchrony parameters including QRS duration and QRS area | Acquired from EP system during procedure | 0.5 hour |
| Mechanical parameters including Ts-SD and IVMD | Acquired by an echocardiologist during procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yangang Su, MD | Shanghai Zhongshan Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 180 Fenglin Road | Shanghai | 200032 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36306335 | Derived | Liang Y, Wang J, Gong X, Lu H, Yu Z, Zhang L, Li M, Pan L, Chen X, Cui J, Zhang W, Li R, Zhou X, Huang W, Su Y, Ge J. Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure. Circ Arrhythm Electrophysiol. 2022 Nov;15(11):e011181. doi: 10.1161/CIRCEP.122.011181. Epub 2022 Oct 28. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D058406 | Cardiac Resynchronization Therapy |
| ID | Term |
|---|---|
| D002304 | Cardiac Pacing, Artificial |
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
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| biventricular pacing |
| Procedure |
biventricular pacing |
|
| 0.5 hour |