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The aim of this study is to test if an extract of Turmeric can alleviate symptoms of osteoarthritis in volunteers with osteoarthritis of the hip and or knee.
The included volunteers, who are devided into two groups either placebo or turmeric extract, will be tested using WOMAC questionnaires focussing on pain, stiffness and daily activity. In addition different aspects of quality of life will be evaluated and the consumption of rescue medication will be recorded in patients personal diary.
The treatment period is 3 month with the posibility to continue for an additional 3 month.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | one capsule daily |
|
| Turmeric extract | Active Comparator | one capsule daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement | Placebo in gelatin capsules |
| |
| Turmeric |
| Measure | Description | Time Frame |
|---|---|---|
| Pain | Difference in WOMAC pain on a 100 mm VAS scale (high levels worse) | 3 month |
| Pain | Difference in WOMAC pain on a 100 mm VAS scale (high levels worse) | 6 month |
| ADL (Activity of daily living) | Difference in WOMAC ADL on a 100 mm VAS scale (high levels worse) | 3 month |
| ADL (Activity of daily living) | Difference in WOMAC ADL on a 100 mm VAS scale (high levels worse) | 6 month |
| Rescue medication | Consumption of rescue medication from diaries (mg) | 3 month |
| Rescue medication | Consumption of rescue medication from diaries (mg) | 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Stiffness of joints | Difference in stiffness of joints on a 100 mm VAS scale (higher values worse) | 3 month |
| Stiffness of joints | Difference in stiffness of joints on a 100 mm VAS scale (higher values worse) |
| Measure | Description | Time Frame |
|---|---|---|
| SF-12 (Quality of life) | Quality of life estimated on a numerical scale (1-3 and 1-6) | 3 month |
| SF-12 (quality of life) | Quality of life estimated on a numerical scale (1-3 and 1-6) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kaj W Hansen, Prof, DMSCi | University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutrition, Exercise and Sports | Copenhagen | 1958 Frb. C | Denmark |
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| ID | Term |
|---|---|
| D018771 | Arthralgia |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D003474 | Curcumin |
| ID | Term |
|---|---|
| D036381 | Diarylheptanoids |
| D006536 | Heptanes |
| D000473 | Alkanes |
| D006839 | Hydrocarbons, Acyclic |
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Half of the volunteers are given placebo and half of the volunteers are given Turmeric extract
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| Dietary Supplement |
Turmeric in gelatin capsules |
|
| 6 month |
| The volunteer evaluation of Global Disease Severity (PGAD) | PGAD is measured on a 100 mm VAS scale (higher values worse) | 3 month |
| The volunteer evaluation of Global Disease Severity (PGAD) | PGAD is measured on a 100 mm VAS scale (higher values worse) | 6 month |
| 6 month |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |