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Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the treatment patterns, achievement of treatment targets and maintenance of response.
Upadacitinib is a drug approved for the treatment of moderately to severely active rheumatoid arthritis. Adult participants with moderate to severe RA who have been prescribed upadacitinib by their physicians will be enrolled. Approximately, 1660 participants will be enrolled this study, worldwide.
Participants will not receive Upadacitinib as part of this study, but will be followed for response to treatment for up to 24 months.
There may be higher burden for participants in this trial compared to their standard of care. Participants will attend regular visits, every 3 months, during the course of the study at a hospital or clinic and will be asked to provide additional information by questionnaire at each visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants receiving Upadacitinib | Participants receiving Upadacitinib for moderate to severe rheumatoid arthritis (RA). |
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| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Participants Who Achieve Remission | Remission is defined as Disease Activity Score at 28 joints (DAS28) C-reactive Protein (CRP)<2.6. | At Month 6 |
| Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission | Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP. | At Month 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission | Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP. | At Month 24 |
| Percentage of Participants Who Achieve Low Disease Activity (LDA) at 6 months that maintain LDA |
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Inclusion Criteria:
Exclusion Criteria:
- Prior treatment with Upadacitinib.
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Adults receiving Upadacitinib according to the product prescribing information, for moderate to severe active Rheumatoid Arthritis (RA).
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| Name | Affiliation | Role |
|---|---|---|
| ABBVIE INC. | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Italiano La Plata /ID# 222190 | La Plata | Buenos Aires | 1902 | Argentina | ||
| CER Instituto Medico /ID# 222193 |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41968259 | Derived | Baldi C, Celletti E, Bugatti S, Govoni M, Cazzato M, Picchianti Diamanti A, Fornaro M, Guggino G, Navarini L, D'Agostino MA, Quartuccio L, Ciccia F, Dagna L, Stobbione P, Triggiani M, Viapiana O, Giardina A, Moroncini G, Caporali R, Bazzani C, Tirri E, Lomater C, Di Fino S, Morello F, Selmi C. Achievement and Maintenance of Remission with Upadacitinib in Patients with Moderate-to-Severe Rheumatoid Arthritis in Italy: 1-Year Data from UPHOLD, a Prospective Real-World Observational Study. Rheumatol Ther. 2026 Jun;13(3):767-784. doi: 10.1007/s40744-026-00845-2. Epub 2026 Apr 12. | |
| 41854829 |
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LDA is defined as DAS28-CRP≤3.2. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP. |
| Through Month 24 |
| Percentage of Participants Who Achieve Remission at 3 Months and Maintain Remission | Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP. | Through Month 24 |
| Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission Grouped by Glucocorticoid Dose | Remission is defined as DAS28-CRP<2.6. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP. | At Month 12 |
| Percentage of Participants Who Achieve LDA at 3 months that maintain LDA Grouped by Glucocorticoid Dose | LDA is defined as DAS28-CRP≤3.2. Maintaining remission is defined as no more than 0.6 point increase in DAS28-CRP. | Through Month 6 |
| Percentage of Participants in LDA that Achieve Glucocorticoid Dose <5 mg/Day Per Visit | LDA is defined as DAS28-CRP<3.2. | Through Month 24 |
| Percentage of Participants in Remission that Achieve Glucocorticoid Dose <5 mg/Day Per Visit | Remission is defined as DAS28-CRP<2.6. | Through Month 24 |
| Percentage of Participants Who Achieved a Glucocorticoid Dose <5 mg/Day Without Conventional Synthetic Disease Modifying Anti Rheumatic Drug (csDMARD) Intensification | Percentage of participants who achieved a glucocorticoid dose <5 mg/day without csDMARD intensification. | At Month 6 |
| Percentage of Participants Who Initiated Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) That Moved to Monotherapy (+/- Glucocorticoids) | Percentage of participants who initiated Upadacitinib as combination therapy (csDMARD +/- Glucocorticoids) that moved to monotherapy (+/- glucocorticoids). | Through Week 24 |
| Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Combination Therapy Strategy | Remission is defined as DAS28-CRP<2.6. | Through Month 24 |
| Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Combination Therapy Strategy | LDA is defined as DAS28-CRP<3.2. | Through Month 24 |
| Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Monotherapy | Remission is defined as DAS28-CRP<2.6. | Through Month 24 |
| Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Monotherapy | LDA is defined as DAS28-CRP<3.2. | Through Month 24 |
| Percentage of Participants Who Do Not Achieve Remission at Any Point in the Study | Remission is defined as DAS28-CRP<2.6. | Through Month 24 |
| Time to the Discontinuation of Upadacitinib | Time to the discontinuation of Upadacitinib. | Through Month 24 |
| Time to First Treatment Adjustment | Treatment Adjustment is defined as treatment escalation/de-escalation/ addition/withdrawal. | Baseline (Month 0) Through Month 24 |
| Percentage of Participants Achieving LDA Grouped by Therapy Strategy | LDA is defined as DAS28-CRP<3.2, Simplified Disease Activity Index (SDAI) ≤11 and Clinical Disease Activity Index (CDAI) ≤10. | Through Month 24 |
| Percentage of Participants Achieving Remission Grouped by Therapy Strategy | Remission is defined as DAS28-CRP<2.6, SDAI≤3.3 and CDAI ≤2.8. | Through Month 24 |
| Change in Medication Burden Treatment Burden Questionnaire (TBQ) in Participants, Grouped by Therapy Strategy | The TBQ is composed of 13 items rated on a Likert scale ranging from 0 (not a problem), to 10 (big problem). scores can be summed into a global score, ranging from 0 to 130. | Through Week 24 |
| Change in Physical Function Health Assessment Questionnaire - Disability Index (HAQ-DI) in Participants, Grouped by Therapy Strategy | HAQ is a widely accepted, validated, rheumatology specific instrument to assess physical function in Rheumatoid Arthritis. It consists of 20 questions, covering eight types of activities. For each question, scores range from 0 to 3 (0 = without any difficulty; 1 = with some difficulty; 2 = with much difficulty or with assistance; 3 = unable to do). HAQ Disability Index (HAQ-DI) score is the average of the highest score in each of the eight categories. | Baseline (Month 0) Through Month 24 |
| Change in Pain Visual Analogue Scale (VAS) in participants, Grouped by Therapy Strategy | A VAS is used to assess worst joint pain in the past 7 days. | Baseline (Month 0) Through Month 24 |
| Change in Morning Stiffness in Participants, Grouped by Therapy Strategy | A numeric rating scale (NRS) is used to assess severity and length of morning stiffness in the past 7 days. | Baseline (Month 0) Through Month 24 |
| Change in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) in Participants, Grouped by Therapy Strategy | The FACIT Fatigue Scale is a short, 13-item, easy to administer tool that measures an individual's level of fatigue during their usual daily activities over the past week. The level of fatigue is measured on a four-point Likert scale (0 = not at all fatigued to 4 = very much fatigued). | Baseline (Month 0) Through Month 24 |
| Quilmes |
| Buenos Aires |
| 1878 |
| Argentina |
| Organizacion Medica de Investigacion (OMI) /ID# 222187 | Ciudad Autonoma de Buenos Aire | Buenos Aires F.D. | 1015 | Argentina |
| CIER Centro de Investigaciones en Enfermedades Reumaticas /ID# 231769 | Ciudad Autonoma de Buenos Aire | Buenos Aires F.D. | 1055 | Argentina |
| Instituto CAICI S.R.L /ID# 222191 | Rosario | Santa Fe Province | 2000 | Argentina |
| CIMER Centro Integral de Medicina Respiratoria /ID# 222188 | San Miguel de Tucumán | Tucumán Province | 4000 | Argentina |
| DOM Centro de Reumatologia /ID# 222194 | Buenos Aires | 1111 | Argentina |
| Instituto Medico Strusberg /ID# 222189 | Córdoba | 5000 | Argentina |
| Instituto de Cardiologia /ID# 226634 | Santiago del Estero | 4200 | Argentina |
| Genesis Research Services /ID# 224060 | Broadmeadow | New South Wales | 2292 | Australia |
| BJC Health /ID# 223884 | Parramatta | New South Wales | 2150 | Australia |
| Private Practice - Scott Walter Graf /ID# 223958 | Adelaide | South Australia | 5000 | Australia |
| Emeritus Research /ID# 223883 | Camberwell | Victoria | 3124 | Australia |
| Joint West Rheumatology /ID# 223886 | Murdoch | Western Australia | 6150 | Australia |
| Klinikum Klagenfurt am Wörthersee /ID# 239628 | Klagenfurt | Carinthia | 9020 | Austria |
| Ordination Dr. Leeb /ID# 224293 | Hollabrunn | Lower Austria | 2020 | Austria |
| Dr. Maya Thun /ID# 224299 | Vienna | State of Vienna | 1010 | Austria |
| Ordination Doz. Grisar /ID# 224298 | Vienna | State of Vienna | 1090 | Austria |
| Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 227853 | Vienna | State of Vienna | 1100 | Austria |
| Dr. Georg Kurtz /ID# 225477 | Gleisdorf | Styria | 8200 | Austria |
| CHU Saint Pierre /ID# 223041 | Brussels | Brussels Capital | 1000 | Belgium |
| Rhumaconsult SPRL /ID# 221825 | Charleroi | Hainaut | 6000 | Belgium |
| Reuma Instituut Hasselt /ID# 221822 | Hasselt | Limburg | 3500 | Belgium |
| Duplicate_CHU UCL Namur - site Godinne /ID# 222797 | Godinne | Namur | 5530 | Belgium |
| Algemeen Stedelijk Ziekenhuis /ID# 224121 | Aalst | Oost-Vlaanderen | 9300 | Belgium |
| Private practice Sint-Niklaas /ID# 224123 | Sint-Niklaas | Oost-Vlaanderen | 9100 | Belgium |
| Onze Lieve Vrouw Hospital /ID# 223042 | Aalst | 9300 | Belgium |
| AZ Sint-Jan Brugge /ID# 223713 | Bruges | 8000 | Belgium |
| AZ Sint Lucas /ID# 223093 | Bruges | 8310 | Belgium |
| Reumacentrum /ID# 222799 | Genk | 3600 | Belgium |
| ReumaClinic /ID# 221353 | Genk | 3600 | Belgium |
| Maertens, Gistel, BE /ID# 221823 | Gistel | 8470 | Belgium |
| CHU de Liege /ID# 222201 | Liège | 4000 | Belgium |
| AZ Alma Campus Sijsele /ID# 222214 | Sijsele | 8340 | Belgium |
| Centre Hospitalier de Laon /ID# 224857 | Laon | Aisne | 02001 | France |
| Polyclinique saint Odilon /ID# 225576 | Moulins | Allier | 03000 | France |
| CH Cannes - les Broussailles /ID# 226160 | Cannes | Alpes-Maritimes | 06414 | France |
| CHU Strasbourg - Hopital de Hautepierre /ID# 222450 | Strasbourg | Bas-Rhin | 67200 | France |
| Hopital Saint Joseph /ID# 227221 | Marseille | Bouches-du-Rhone | 13008 | France |
| cabinet liberal- Dr CORNILLE /ID# 227869 | Caen | Calvados | 14000 | France |
| Centre Hospitalier d'Angouleme /ID# 226064 | Angoulême | Charente | 16959 | France |
| CHU Dijon /ID# 223799 | Dijon | Cote-d Or | 21000 | France |
| CH Georges Renon /ID# 225197 | Niort | Deux-Sevres | 79028 | France |
| CHU de Besancon - Jean Minjoz /ID# 222463 | Besançon | Doubs | 25030 | France |
| Cabinet de rhumatologie /ID# 227740 | Mennecy | Essonne | 91540 | France |
| Cabinet Rhumatologie St Michel Sur Orge /ID# 225176 | Saint-Michel-sur-Orge | Essonne | 91240 | France |
| Hopital de la Cavale Blanche /ID# 222462 | Brest | Finistere | 29200 | France |
| CH des Pays de Morlaix /ID# 223795 | Morlaix | Finistere | 29600 | France |
| CHU Limoges - Dupuytren 1 /ID# 222457 | Limoges | Franche-Comte | 87042 | France |
| CHU Bordeaux - Hopital Pellegrin /ID# 224837 | Bordeaux | Gironde | 33076 | France |
| CHU Toulouse - Hopital Purpan /ID# 223150 | Toulouse | Haute-Garonne | 31059 | France |
| CH Bigorre - Site de la Gespe /ID# 225141 | Tarbes | Hautes-Pyrenees | 65013 | France |
| CH Roubaix - Hopital Victor Provo /ID# 225032 | Roubaix | Hauts-de-France | 59100 | France |
| Clinique Beau Soleil /ID# 224238 | Montpellier | Herault | 34070 | France |
| CHU Montpellier - Hopital Saint Eloi /ID# 222452 | Montpellier | Herault | 34295 | France |
| CHU Montpellier - Hopital Saint Eloi /ID# 223394 | Montpellier | Herault | 34295 | France |
| CHU Grenoble - Hopital Michallon /ID# 223211 | La Tronche | Isere | 38700 | France |
| Cabinet médical /ID# 225000 | Les Abrets En Dauphine | Isere | 38490 | France |
| Cabinet médical /ID# 225321 | Reims | Marne | 51100 | France |
| Cabinet de Rhumatologie Poincare /ID# 224755 | Thionville | Moselle | 57100 | France |
| Cabinet liberal - Compiegne - Dr Banse /ID# 227099 | Compiègne | Oise | 60200 | France |
| Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 222986 | Paris | Paris | 75679 | France |
| CHU de Nantes, Hotel Dieu -HME /ID# 225787 | Nantes | Pays de la Loire Region | 44000 | France |
| CH Roanne /ID# 224729 | Roanne | Pays de la Loire Region | 42300 | France |
| CHU Nice -Hopital Pasteur /ID# 222460 | Nice | Provence-Alpes-Côte d'Azur Region | 06002 | France |
| Infirmerie Protestante /ID# 222438 | Caluire-et-Cuire | Rhone | 69300 | France |
| HCL - Hopital Lyon Sud /ID# 222447 | Pierre-Bénite | Rhone | 69495 | France |
| Cabinet medical /ID# 225366 | Aix-les-Bains | Savoie | 73100 | France |
| CHU Amiens-Picardie Site Sud /ID# 222444 | Amiens | Somme | 80054 | France |
| Cabinet libéral du Dr PAUPIERE /ID# 238723 | Péronne | Somme | 80200 | France |
| Cabinet medical /ID# 224850 | Albi | Tarn | 81000 | France |
| CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 229086 | La Roche-sur-Yon | Vendee | 85000 | France |
| CH du Pays d'AIX /ID# 229561 | Aix-en-Provence | 13616 | France |
| Cabinet Novel d'Annecy /ID# 232310 | Annecy | 74000 | France |
| Centre Hospitalier d'Arras /ID# 223172 | Arras | 62022 | France |
| Centre Hospitalier de Boulogne Sur Mer /ID# 222991 | Boulogne-sur-Mer | 62200 | France |
| Centre Hospitalier Jean Rougie /ID# 224242 | Cahors | 46005 | France |
| CHRU Tours - Hopital Trousseau /ID# 222445 | Chambray-lès-Tours | 37170 | France |
| Centre Hospitalier de CHOLET /ID# 222455 | Cholet | 49300 | France |
| Hia Percy /Id# 225642 | Clamart | 92190 | France |
| CHU Clermont Ferrand - Hopital Gabriel Montpied /ID# 223801 | Clermont-Ferrand | 63000 | France |
| C. H. Sud Francilien /ID# 222446 | Corbeil-Essonnes | 91106 | France |
| Cabinet medical /ID# 225142 | Haguenau | 67500 | France |
| CH La Rochelle - Hopital Saint Louis /ID# 224240 | La Rochelle | 17019 | France |
| CH Emile Roux Le Puy en Velay /ID# 223688 | Le Puy-en-Velay | 43000 | France |
| CHU Lille - Hôpital Roger Salengro /ID# 223170 | Lille | 59037 | France |
| Clinique de la Sauvegarde /ID# 223424 | Lyon | 69009 | France |
| CH Princesse Grace /ID# 222451 | Monaco | 98000 | France |
| Ch Montauban /Id# 231854 | Montauban | 82000 | France |
| ELSAN - Clinique du Pont de Chaume /ID# 224898 | Montauban | 82000 | France |
| Ch Mulhouse /Id# 223442 | Mulhouse | 68100 | France |
| Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 223591 | Orléans | 45067 | France |
| AP-HP - Hopital Saint-Antoine /ID# 222441 | Paris | 75012 | France |
| Hopital Pitie Salpetriere /ID# 222443 | Paris | 75013 | France |
| Cabinet medical /ID# 224855 | Paris | 75014 | France |
| Centre de Soins Osteoarticulaires Ambulatoires /ID# 224737 | Paris | 75015 | France |
| AP-HP - Hopital Bichat - Claude-Bernard /ID# 222449 | Paris | 75018 | France |
| GH Diaconesses Croix Saint-Simon /ID# 229126 | Paris | 75020 | France |
| CHU de Rennes - Hospital Sud /ID# 222458 | Rennes | 35203 | France |
| Clinique Saint-Hilaire /ID# 223833 | Rouen | 76000 | France |
| Hôpital Charles-Nicolle /ID# 223589 | Rouen | 76000 | France |
| Hôpital d'instruction des armées Bégin /ID# 222440 | Saint-Mandé | 94163 | France |
| CH Saint Nazaire /ID# 225750 | Saint-Nazaire | 44600 | France |
| Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 222456 | Saint-Priest-en-Jarez | 42270 | France |
| Cabinet rhumatologie Dr NECTOUX /ID# 225828 | Sainte-Maxime | 83120 | France |
| Groupe Médical Spécialisé - Le Premium /ID# 223719 | Strasbourg | 67000 | France |
| Hopital Avicenne - APHP /ID# 224248 | Bobigny | Île-de-France Region | 93000 | France |
| Praxis Dr. Haas /ID# 225187 | Tübingen | Baden-Wurttemberg | 72072 | Germany |
| Rheumatologische-Immunologische Praxis Templin /ID# 226924 | Templin | Brandenburg | 17268 | Germany |
| ACURA Rheumazentrum Baden-Bade /ID# 225225 | Baden-Baden | 76530 | Germany |
| Rheumapraxis Prof Dr Karin Manger /ID# 224086 | Bamberg | 96047 | Germany |
| Praxis fuer Rheumatologie und Innere Medizin /ID# 225222 | Berlin | 12163 | Germany |
| Eisterhues, Braunschweig, DE /ID# 225186 | Braunschweig | 38100 | Germany |
| Rheumatologie in Veedel /ID# 224999 | Cologne | 50825 | Germany |
| Dres. Karger/Baerlecken /ID# 224809 | Cologne | 50996 | Germany |
| Praxis Dilltal /ID# 226925 | Ehringshausen | 35630 | Germany |
| MVZ Ambulantes Rheumazentrum Erfurt /ID# 224812 | Erfurt | 99096 | Germany |
| Helios Fachklinik Vogelsang-Gommern /ID# 222949 | Gommern | 39245 | Germany |
| Asklepios MVZ Nord SH GmbH /ID# 225048 | Hamburg | 20097 | Germany |
| Heilig, Heidelberg, DE /ID# 225223 | Heidelberg | 69120 | Germany |
| Praxis internistische Rheumatologie /ID# 239226 | Leipzig | 04129 | Germany |
| Dres. Teipel/Toussaint/Saech /ID# 226923 | Leverkusen | 51373 | Germany |
| Aurich & Sieburg, Magdeburg /ID# 230701 | Magdeburg | 39104 | Germany |
| Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 223866 | Pfarrkirchen | 84347 | Germany |
| MVZ für Rheumatologie Dr. M. Welcker /ID# 226926 | Planegg | 82152 | Germany |
| Krankenhaus der Barmherzigen Brüder Trier /ID# 226927 | Trier | 54292 | Germany |
| Olympion General Clinic /ID# 224130 | Pátrai | Achaia | 25443 | Greece |
| 251 Airforce General Hospital /ID# 225065 | Athens | Attica | 11525 | Greece |
| General Hospital of Athens Gennimatas /ID# 225064 | Athens | Attica | 11527 | Greece |
| General Hospital of Athens Ippokratio /ID# 224164 | Athens | Attica | 11527 | Greece |
| University General Hospital Attikon /ID# 224136 | Athens | Attica | 12462 | Greece |
| General Hospital Asklepieio Voulas /ID# 224131 | Athens | Attica | 16673 | Greece |
| University General Hospital of Heraklion PA.G.N.I /ID# 224133 | Heraklion | Crete | 71500 | Greece |
| University General Hospital of Alexandroupolis /ID# 224880 | Alexandroupoli | Evros | 68100 | Greece |
| Naval Hospital of Athens /ID# 224135 | Athens | 11521 | Greece |
| General Hospital of Patras Agios Andreas /ID# 224132 | Pátrai | 26335 | Greece |
| Bioclinic Thessaloniki /ID# 224879 | Thessaloniki | 54622 | Greece |
| General Hospital of Thessaloniki Hippokrateio /ID# 229965 | Thessaloniki | 54642 | Greece |
| Euromedica General Clinic /ID# 224134 | Thessaloniki | 54645 | Greece |
| St James Hospital /ID# 224201 | Dublin | Dublin | D08 NHY1 | Ireland |
| Hermitage Medical Clinic /ID# 239556 | Dublin | Dublin | D20 W722 | Ireland |
| St Vincent's University Hospital /ID# 224200 | Elm Park | Dublin | D04 T6F4 | Ireland |
| Tallaght University Hospital /ID# 231260 | Tallaght | Dublin | D24 NR0A | Ireland |
| Meir Medical Center /ID# 222116 | Kfar Saba | Central District | 4428164 | Israel |
| HaEmek Medical Center /ID# 222138 | Afula | H_efa | 1834111 | Israel |
| Hillel Yaffe Medical Center /ID# 222170 | Hadera | H_efa | 38100 | Israel |
| Rambam Health Care Campus /ID# 222118 | Haifa | H_efa | 3109601 | Israel |
| The Lady Davis Carmel Medical Center /ID# 223851 | Haifa | H_efa | 34362 | Israel |
| Galilee Medical Center /ID# 222113 | Nahariya | Northern District | 2210001 | Israel |
| The Chaim Sheba Medical Center /ID# 222034 | Ramat Gan | Tel Aviv | 5265601 | Israel |
| Tel Aviv Sourasky Medical Center /ID# 222117 | Tel Aviv | Tel Aviv | 6423906 | Israel |
| Rabin Medical Center /ID# 222694 | Haifa | 4941492 | Israel |
| Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 229440 | Torette | Ancona | 60020 | Italy |
| Azienda Ospedaliero Universitaria di Ferrara - Ospedale Sant'Anna /ID# 228788 | Cona | Ferrara | 44124 | Italy |
| ASL 3 Genovese - Ospedale la Colletta /ID# 228892 | Arenzano | Genova | 16011 | Italy |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 229061 | Rome | Lazio | 00168 | Italy |
| Ospedale San Raffaele IRCCS /ID# 229059 | Milan | Milano | 20132 | Italy |
| ASST Grande Ospedale Metropolitano Niguarda /ID# 228807 | Milan | Milano | 20162 | Italy |
| Istituto Clinico Humanitas /ID# 227943 | Rozzano | Milano | 20089 | Italy |
| Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 229063 | Rome | Roma | 00128 | Italy |
| Sapienza University /ID# 228014 | Rome | Roma | 00161 | Italy |
| Ospedale Mauriziano di Torino /ID# 228888 | Turin | Torino | 10128 | Italy |
| Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 228889 | Alessandria | 15100 | Italy |
| Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 228580 | Bari | 70124 | Italy |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 228967 | Bergamo | 24127 | Italy |
| ASST Spedali civili di Brescia /ID# 228970 | Brescia | 25123 | Italy |
| Ospedale Ss. Annunziata /ID# 228809 | Chieti | 66100 | Italy |
| ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 228556 | Milan | 20122 | Italy |
| Azienda Ospedaliero-Universitaria di Modena /ID# 228554 | Modena | 41124 | Italy |
| AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 229057 | Naples | 80138 | Italy |
| Ospedale San Giovanni Bosco /ID# 228552 | Naples | 80144 | Italy |
| Azienda Ospedaliera Civico Di Cristina Benfratelli- P.O. Civico /ID# 228912 | Palermo | 90127 | Italy |
| Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228160 | Palermo | 90127 | Italy |
| Fondazione IRCCS Policlinico /ID# 227937 | Pavia | 27100 | Italy |
| Azienda Ospedaliero Universitaria Pisana /ID# 228550 | Pisa | 56126 | Italy |
| Azienda Ospedaliera Regionale San Carlo /ID# 228648 | Potenza | 85100 | Italy |
| Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 227942 | Rome | 00189 | Italy |
| Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d'Aragona /ID# 229065 | Salerno | 84131 | Italy |
| Azienda Ospedaliero-Universitaria Senese-Ospedale Santa Maria delle Scotte /ID# 227938 | Siena | 53100 | Italy |
| Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 228551 | Udine | 33100 | Italy |
| Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Trento /ID# 228553 | Verona | 37126 | Italy |
| Mubarak Hospital /ID# 224139 | Hawalli | 46300 | Kuwait |
| Ameeri Hospital /ID# 224140 | Kuwait City | 35002 | Kuwait |
| KOC Hospital /ID# 224138 | Kuwait City | 60000 | Kuwait |
| Centro Integral en Reumatologia S.A de C.V /ID# 224363 | Guadalajara | Jalisco | 44160 | Mexico |
| Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 224361 | Guadalajara | Jalisco | 44650 | Mexico |
| Private Office Dr. Orozco /ID# 243257 | Guadalajara | Jalisco | 44650 | Mexico |
| Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 224364 | Guadalajara | Jalisco | 44690 | Mexico |
| RM Pharma Specialists S.A de C.V. /ID# 224359 | Mexico City | Mexico City | 03100 | Mexico |
| CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 240836 | Mexico City | Mexico City | 11850 | Mexico |
| Consultorio Medico Privado - Miryam Eguia Bernal /Id# 243255 | Monterrey | Nuevo León | 64000 | Mexico |
| Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 224360 | Mexico City | 11650 | Mexico |
| Consultorio Privado Jorge Rojas Serrano /Id# 243258 | Puebla City | 72550 | Mexico |
| LLC MC RevmaMed /ID# 239162 | Syktyvkar | Komi | 167031 | Russia |
| Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 224852 | Moscow | Moscow Oblast | 129110 | Russia |
| Samara Regional Clinical Hospital n.a. V. D. Seredavin /ID# 227852 | Samara | Samara Oblast | 443095 | Russia |
| Nort-Western State Medical University n.a. Mechnikov /ID# 223419 | Saint Petersburg | Sankt-Peterburg | 193015 | Russia |
| GBUZ TO Regional Clinical Hospital No. 1 /ID# 241113 | Tyumen | Tyumen Oblast | 625032 | Russia |
| District clinical hospital /ID# 227662 | Khanty-Mansyisk | 628011 | Russia |
| City Clinical Hospital #52 /ID# 242947 | Moscow | 123182 | Russia |
| Omsk Regional Clinic Hospital /ID# 232029 | Omsk | 644111 | Russia |
| Orenburg State Medical University /ID# 243615 | Orenburg | 460000 | Russia |
| Republican hospital named after V.A. Baranov /ID# 227661 | Petrozavodsk | 185019 | Russia |
| Clinical Rheumatologic Hospital No 25 /ID# 242475 | Saint Petersburg | 190068 | Russia |
| Military Medical Academy n.a. Kirov /ID# 242351 | Saint Petersburg | 194044 | Russia |
| Clinic of Samara State Medical University /ID# 241168 | Samara | 443079 | Russia |
| Budgetary Institution of the Khanty-Mansiysk Autonomous Okrug-Yugra Surgut Dist /ID# 243313 | Surgut | 628400 | Russia |
| Nebbiolo Clinical Research Center /ID# 224900 | Tomsk | 634009 | Russia |
| Ulyanovsk Regional Clinical Hospital /ID# 239164 | Ulyanovsk | 432017 | Russia |
| Voronezh State Medical Univers /ID# 224854 | Voronezh | 394036 | Russia |
| Yaroslavl State Medicat University /ID# 224851 | Yaroslavl | 150000 | Russia |
| Saudi German Hospital Jeddah /ID# 243234 | Jeddah | 22236 | Saudi Arabia |
| King Abdulaziz University Hospital /ID# 222724 | Jeddah | 22252 | Saudi Arabia |
| International Medical Center /ID# 243235 | Jeddah | 22382 | Saudi Arabia |
| Saudi German Hospital /ID# 224137 | Mushait | 61961 | Saudi Arabia |
| King Fahad Medical City /ID# 222917 | Riyadh | 11525 | Saudi Arabia |
| Complejo Hospitalario Universitario A Coruña /ID# 231818 | A Coruña | A Coruna | 15006 | Spain |
| Hospital de Mérida /ID# 231826 | Mérida | Badajoz | 06800 | Spain |
| Hospital Universitari Mútua Terrassa /ID# 231822 | Terrassa | Barcelona | 08221 | Spain |
| Hospital de Viladecans /ID# 231823 | Viladecans | Barcelona | 08840 | Spain |
| Hospital Virgen del Puerto /ID# 240149 | Plasencia | Caceres | 10600 | Spain |
| Hospital Universitario de Jerez de la Frontera /ID# 231844 | Jerez de la Frontera | Cadiz | 11407 | Spain |
| Hospital Universitario Reina Sofia /ID# 231843 | Córdoba | Cordoba | 14004 | Spain |
| Hospital Universitario de Getafe /ID# 231825 | Getafe | Madrid | 28905 | Spain |
| Hospital General Universitario Santa Lucia /ID# 238780 | Cartagena | Murcia | 30202 | Spain |
| Hospital Clinico Universitario Virgen de la Arrixaca /ID# 231847 | El Palmar | Murcia | 30120 | Spain |
| Hospital Rafael Mendez /ID# 231846 | Lorca | Murcia | 30817 | Spain |
| Hospital Xeral Cies (CHUVI) /ID# 231819 | Vigo | Pontevedra | 36204 | Spain |
| Hospital Universitario Canarias /ID# 231848 | San Cristóbal de La Laguna | Santa Cruz De Tenerife | 38320 | Spain |
| Hospital Ernest Lluch Martin /ID# 238779 | Calatayud | Zaragoza | 50299 | Spain |
| Hospital Universitario Torrecardenas /ID# 241931 | Almería | 04009 | Spain |
| Hospital Perpetuo Socorro /ID# 231827 | Badajoz | 06010 | Spain |
| Hospital Parc de Salut del Mar /ID# 240000 | Barcelona | 08003 | Spain |
| Hospital Santa Creu i Sant Pau /ID# 231821 | Barcelona | 08041 | Spain |
| Hospital General de Granollers /ID# 238778 | Barcelona | 08042 | Spain |
| Hospital Universitario Virgen de las Nieves /ID# 231841 | Granada | 18014 | Spain |
| Hospital Juan Ramon Jimenez /ID# 231840 | Huelva | 21005 | Spain |
| Hospital Universitario de Jaen /ID# 231842 | Jaén | 23007 | Spain |
| Hospital Universitario Ramon y Cajal /ID# 241901 | Madrid | 28034 | Spain |
| Hospital Universitario Virgen de la Victoria /ID# 240150 | Málaga | 29010 | Spain |
| Hospital Universitario Virgen Macarena /ID# 231837 | Seville | 41009 | Spain |
| Hospital Universitario Virgen del Rocio /ID# 231836 | Seville | 41013 | Spain |
| Hospital Universitario Virgen de Valme /ID# 231838 | Seville | 41014 | Spain |
| Hospital Royo Villanova /ID# 231824 | Zaragoza | 50015 | Spain |
| Kantonsspital Aarau AG /ID# 222354 | Aarau | Canton of Aargau | 5001 | Switzerland |
| Universitätsspital Basel /ID# 224160 | Basel Town | Canton of Basel-City | 4031 | Switzerland |
| Kantonsspital St. Gallen /ID# 224158 | Sankt Gallen | Canton of St. Gallen | 9007 | Switzerland |
| CHUV, Centre hospitalier universitaire vaudois /ID# 224161 | Lausanne | Canton of Vaud | 1011 | Switzerland |
| Rheumatologisches Versorgungszentrum Weinfelden /ID# 222346 | Weinfelden | Thurgau | 8570 | Switzerland |
| Inselspital, Universitaetsspital Bern /ID# 224951 | Bern | 3010 | Switzerland |
| HFR Fribourg - Hôpital cantonal /ID# 224163 | Fribourg | 1708 | Switzerland |
| National Taiwan University Hospital /ID# 241050 | Taipei City | Taipei | 100 | Taiwan |
| Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 241052 | Kaohsiung City | 807 | Taiwan |
| China Medical University Hospital /ID# 241051 | Taichung | 40447 | Taiwan |
| Chi-Mei Medical Center /ID# 241745 | Tainan | 71004 | Taiwan |
| Tri-Service General Hospital /ID# 241746 | Taipei | 11490 | Taiwan |
| Linkou Chang Gung Memorial Hospital /ID# 241053 | Taoyuan City | 333 | Taiwan |
| Cleveland Clinic Abu Dhabi /ID# 223176 | Abu Dhabi | United Arab Emirates |
| Integrated Rheumatology and Arthritis Center /ID# 223177 | Dubai | 334224 | United Arab Emirates |
| Departnent of Medicine-Rheumatology Al Baraha Hospital and Al Qasmi Hospital Min /ID# 223178 | Dubai | United Arab Emirates |
| Drt Sulaiman Al Habib Hospital /ID# 226575 | Dubai | United Arab Emirates |
| Asociacion Española /ID# 222009 | Montevideo | 11200 | Uruguay |
| Medica Uruguaya /ID# 222008 | Montevideo | 11600 | Uruguay |
| Derived |
| Ostor A, Feist E, Sidiropoulos P, Avouac J, Rebella M, Namas R, Buttgereit F, Conaghan PG, Romero AB, McDearmon-Blondell EL, Lagunes-Galindo I, Gao T, Kadakia A, Shaw T, Attar S. Achievement and Maintenance of Disease Targets with Upadacitinib in Rheumatoid Arthritis: 2-Year Outcomes from the UPHOLD Real-World Study. Rheumatol Ther. 2026 Jun;13(3):659-676. doi: 10.1007/s40744-026-00826-5. Epub 2026 Mar 19. |
| 41761286 | Derived | Hugle T, Prillwitz H, Scholz G, Kyburz D, Dudler J, Schmiedeberg K, Zanisi L, Harrer Kuster MD, Roulin PS, Rubbert-Roth A. Sleep improvement in patients with rheumatoid arthritis treated with upadacitinib in real-world practice: results from the SLEERA study. Arthritis Res Ther. 2026 Feb 27;28(1):80. doi: 10.1186/s13075-026-03766-1. |
| 40211417 | Derived | Ostor A, Feist E, Sidiropoulos P, Avouac J, Rebella M, Namas R, McDearmon-Blondell E, Gao T, Lagunes-Galindo I, Strengholt S, Zisman D, Attar S. Achievement of treatment targets and maintenance of response with upadacitinib in patients with moderate-to-severe rheumatoid arthritis in real-world practice: 1-year outcomes from the UPHOLD observational study. Arthritis Res Ther. 2025 Apr 10;27(1):84. doi: 10.1186/s13075-025-03528-5. |
| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
Not provided
Not provided