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| Name | Class |
|---|---|
| Marywood University | OTHER |
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A comparison of acute tart cherry formations (juice vs. powdered) and doses (single vs. twice daily) on inflammation and oxidative capacity.
Participants will be randomly allocated to a group: one tart cherry capsule daily, two tart cherry capsules daily, one 8oz. bottle of tart cherry juice daily, two 8oz. bottles of tart cherry juice taken 8 hours apart, one placebo pill, and one 8oz. bottle of placebo. Participants will arrive to the lab at 8 am after an overnight fast of 10 hours. They will provide a blood sample and then ingest their study treatment. Participants will stay in the lab for a further 2 hours for additional blood draws then return to the lab in 6 hours for another blood draw. At this time if they are in a twice daily group they will receive their second treatment for the day. All participants will come back to the lab 24 hours later where they will give a blood sample and receive their next treatment. If they are in the twice daily group they will be provided with their next dose and given instructions to consume it in 8 hours. Participants will arrive 24 hours later for a final blood draw with no supplementation.
Blood samples will be measured pre-ingestion, 1 hour, 2 hours, 8 hours, 24 hours and 48 hours post-ingestion. Samples will be analyzed for plasma oxygen radical absorbance capacity (ORAC), uric acid (UA), and C-reactive protein (CRP).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single dose tart cherry capsule | Experimental | single dose tart cherry capsule |
|
| double dose tart cherry capsule | Experimental | double dose tart cherry capsule |
|
| single dose tart cherry juice | Experimental | single dose tart cherry juice |
|
| double dose tart cherry juice | Experimental | double dose tart cherry juice |
|
| single placebo capsule | Experimental | single placebo capsule |
|
| single placebo juice | Experimental | single placebo juice |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tart cherry | Dietary Supplement | Either tart cherry juice or freeze dried powdered tart cherry in capsule was given |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in c-reactive protein | c-reactive protein (mg/L) measured via assay | 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion |
| Change in uric acid | uric acid (mg/dL) measured via assay | 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion |
| Change in oxidative capacity | oxygen radical absorbance capacity (uM Trolox equivalents) measured via assay | 1 hour, 2 hours, 8 hours, 24 hours, and 48 hours post ingestion |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33506357 | Derived | Hillman AR, Uhranowsky K. Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity. Plant Foods Hum Nutr. 2021 Mar;76(1):83-89. doi: 10.1007/s11130-021-00879-7. Epub 2021 Jan 27. |
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upon request
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| placebo | Dietary Supplement | either cornstarch capsule or kool-aid |
|