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"Mosapride citrate is a 5-hydroxytryptamine 4 receptor agonist, and is widely used as an agent to increase intestinal motility. Mosapride citrate has been demonstrated in in vitro and in vivo studies to increase both gastric and colon motility. In a case-control study of patients undergoing colonectomy, mosapride citrate was found to significantly reduce gas passing and defecation time.
Recently, a study reported that mosapride citrate acts on the α7nACh receptor and, consequently, suppresses the inflammatory response of macrophages, thereby suppressing the mechanism that induces paralysis after surgery.
To date, this study is intended to analyze whether mosapride citrate significantly affects the improvement of bowel movement after surgery after gastrectomy."
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mosapride group | Experimental | Patients receive placebo or mosapride citrate (5mg/T) three times a day from the first day after surgery. |
|
| Placebo group | Placebo Comparator | Patients receive placebo instead of mosapride citrate (5mg/T) three times a day from the first day after surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mosapride citrate | Drug | Patients receive mosapride citrate (5mg/T) three times a day from the first day after surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The number of radiopaque markers transferred to the large intestine 3 days after surgery | Intestinal motility after gastrectomy | 3 Days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GangnamSeverance Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D000267 | Tissue Adhesions |
| D045823 | Ileus |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| C062720 | mosapride |
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| Placebo | Drug | Placebo |
|
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D002921 | Cicatrix |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007415 | Intestinal Obstruction |
| D007410 | Intestinal Diseases |