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We investigate whether the intravenously administered human albumin is beneficial to prevent anastomotic leakage after gastric cancer surgery.
Anastomotic leakage after gastric cancer surgery is not very common but it is a very critical postoperative complication. Anastomotic leakage severely compromises the recovery after surgery. It increases the overall burden of patients and hospital resources. Postoperative mortality is higher in patients with anastomotic leakage.
Human albumin is routinely administered after surgery with a unproven hypothesis that the human albumin is beneficial to prevent anastomotic leakage. We investigate whether the intravenously administered human albumin is beneficial to prevent anastomotic leakage after gastric cancer surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Human albumin support | Patients who received intravenous human albumin after gastric cancer surgery |
| |
| No human albumin support | Patients who did not receive intravenous human albumin after gastric cancer surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Human albumin | Biological | Patients received intravenous human albumin after gastric cancer surgery. Overall quantity of human albumin were recorded. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of the rate of anastomotic leakage | The rate of anastomotic leakage were compared among both groups | Up to one months after the discharge of last patient |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with gastric cancer who underwent gastrectomy with adequate lymph node dissection.
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| Name | Affiliation | Role |
|---|---|---|
| Birendra K Sah, PH D | Ruijin Hospital | Principal Investigator |
| Chen Li, PH D | Ruijin Hospital | Study Director |
| Zhenggang Zhu, PH D | Ruijin Hospital | Study Chair |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D057868 | Anastomotic Leak |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D000075462 | Serum Albumin, Human |
| ID | Term |
|---|---|
| D012709 | Serum Albumin |
| D000418 | Albumins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
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| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001798 |
| Blood Proteins |