Fasting mimetic diet (FMD) showed positive effects on cardiovascular risks. Purpose of the trial is to evaluate FMD effects on patients affected by chronic kidney disease (CKD), through the stimulation of kidney stem cells and improving cardiovascular and metabolic status.

From April 2018, the investigators enrolled 13 patients (7 male) with an history of primary glomerulonephritis (GMN) and an eGFR between 60 ml/min and 30 ml/min. Exclusion criteria are: age <18 y.o., age> 65 y.o., secondary GMN, severe heart failure (NYHA IV),ongoing infectious diseases, ongoing neoplasia, hepatic diseases, COPD, inflammatory bowel disease, history of stroke, history of acute coronary disease less than 3 months, pregnancy, refuse informed consent.

Inclusion Criteria:

• History of primary glomerulonephritis
• eGFR between 60 ml/min and 30 ml/min
• age between 18-65 years old

Exclusion Criteria:

• secondary GMN
• severe heart failure (NYHA IV)
• ongoing infectious diseases
• ongoing neoplasia,
• hepatic diseases
• COPD,
• inflammatory bowel disease
• history of stroke
• history of acute coronary disease less than 3 months
• pregnancy
• refuse informed consent.