Exercise, Prediabetes and Diabetes After Renal Transplantation.

Exercise, Prediabetes and Diabetes After Renal Transplantation.

This study is designed to evaluate the feasibility of exercise to reverse prediabetes after transplantation to prevent Posttransplantation Diabetes Mellitus (PTDM).

The hypothesis of the study is that exercise will promote the reversibility to normal glucose metabolism in patients with prediabetes and eventually reduce the incidence of PTDM in renal transplant. The main objective of the study is to induce the reversibility of prediabetes by means of exercise. Additionally, the secondary objectives are: (a) to evaluate the compliance of exercise (b) improvements in metabolic risk factors profile: obesity, triglycerides, blood pressure and HDL cholesterol.

Inclusion Criteria:

• Age > 18 years old.
• Renal transplantation: beyond 6-12 months after transplantation with stable renal function
• IFG: 100-125 mg/dl and IGT 140-199 mg/dl.
• Ability or capacity to perform exercise.

Exclusion Criteria:

• Clinical conditions that preclude the treatment with exercise i.e. clinical instability: active infection, cancer, acute cardiovascular disease, advanced renal disease, pulmonar hypertension, chronic obstructive pulmonary disease, severe reumatological disorders, arthrosis, arthritis limb amputation, etc.
• Inability to understand the protocol.
• Severe psychological disease.
• PTDM.
• Diabetes before transplantation.