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Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| nerve block combined with general anesthesia group | Experimental | Patients in this group receive nerve block combined with general anesthesia. |
|
| spinal anesthesia group | Experimental | Patients in this group receive spinal anesthesia. |
|
| control group | Placebo Comparator | This group is used to obtain the learning effect. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nerve block combined with general anesthesia | Device | Patients in this group receive nerve block combined with general anesthesia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of PND seven days after surgery | seven days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of PND one month after surgery | one month after surgery | |
| Incidence of PND one year after surgery | one year after surgery | |
| Hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhiheng Liu, MD | Contact | +86-0755-83366388 | 15818585570@163.com | |
| Nanbo Luo, MD | Contact | +86-0755-83366388 | 316916645@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shenzhen Second People's Hospital | Recruiting | Shenzhen | Guangdong | 518035 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
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| ID | Term |
|---|---|
| D000768 | Anesthesia, General |
| D000775 | Anesthesia, Spinal |
| ID | Term |
|---|---|
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
| D000765 | Anesthesia, Conduction |
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| spinal anesthesia | Device | Patients in this group receive spinal anesthesia. |
|
| one to two weeks after surgery |
| Number of patients entrance the ward of ICU after surgery | one week post-operation |
| Mortality rate | one year after surgery |
| Postoperative complications | one month post-operation |
| ADL of frontal lobe，temporal lobe and occipital lobe | one day pre-operation, one week post-operation |
| ADL of frontal lobe | one day pre-operation, one week post-operation |
| BOLD of the whole brain | one day pre-operation, one week post-operation |
| ADL of temporal lobe | one day pre-operation, one week post-operation |
| ADL of occipital lobe | one day pre-operation, one week post-operation |
| One year event-free survival | one year after surgery |
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