Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin B12
Coffee consumption has been associated with several risk factors leading to cardiovascular diseases (CVDs), including hyperhomocysteinemia and hyperlipidemia. Frequent coffee consumption has beneficial effects in reducing the risk of diabetes mellitus (DM) type 2, obesity, liver disease, CVDs, some types of cancer, Parkinson's disease, and Alzheimer's disease. Controversies concerning coffee consumption benefits and risks in regards for CVDs were mentioned in many studies. Folic acid and vitamin B12 are necessary vitamins in homocysteine metabolism which is a risk factor for atherosclerosis. Leptin, is a hormone linked to obesity and it could be related to atherosclerosis.
The combined effect of coffee consumption and body weight on the levels of leptin, folic aid, and vitamin B12 is not well studied. In our study, we will study the effect of coffee consumption in males with different body mass indices to see the effect of several important parameters such as leptin, Folic acid, and vitamin B12.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NW/MCC | Normal body mass index (BMI) / with moderate coffee consumption |
| |
| NW/HCC | Normal body mass index (BMI) / with heavy coffee consumption |
| |
| OW/MCC | Overweight / with moderate coffee consumption |
| |
| OW/HCC | Overweight / with heavy coffee consumption |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal BMI and moderate coffee consumption | Behavioral | Normal BMI and moderate coffee consumption |
|
| Measure | Description | Time Frame |
|---|---|---|
| leptin | Plasma Concentration of leptin in ng /ml | Baseline |
| folic acid | Plasma Concentration of folic acid in ng /ml | Baseline |
| Vitamin B12 | Plasma Concentration of Vitamin B12 in pg /ml | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| fasting blood glucose | Plasma Concentration of glucose mg/dL | Baseline |
| lipid profile | Plasma Concentration of LDL, HDL in mg/dl | Baseline |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Only young males are considered
Young male students studying at Applied Science Private University (ASU) in Amman were approached for study participation.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Mahmoud S Abu-samak, PhD | Applied Sciences Private University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Applied Science University | Amman | Jordan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10648261 | Result | Grubben MJ, Boers GH, Blom HJ, Broekhuizen R, de Jong R, van Rijt L, de Ruijter E, Swinkels DW, Nagengast FM, Katan MB. Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr. 2000 Feb;71(2):480-4. doi: 10.1093/ajcn/71.2.480. | |
| 28109191 | Result | Ma Y, Peng D, Liu C, Huang C, Luo J. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases. BMC Cardiovasc Disord. 2017 Jan 21;17(1):37. doi: 10.1186/s12872-017-0475-8. |
Not provided
Not provided
All IPD that underline results in a publication.
When summary data are published
Open access
Not provided
Not provided
Not provided
Not provided
Not provided
Serum samples will be retained
| Normal BMI and heavy coffee consumption | Behavioral | Normal BMI and heavy coffee consumption |
|
| overweight and moderate coffee consumption | Behavioral | overweight and moderate coffee consumption |
|
| overweight and heavy coffee consumption | Behavioral | overweight and heavy coffee consumption |
|
| 33758508 | Derived | Hasoun LZ, Khader HA, Abu-Taha MI, Mohammad BA, Abu-Samak MS. A Cross-Sectional Study on the Combined Effect of Body Weight and Coffee Consumption on Serum Levels of Leptin, Vitamin B12, and Folic Acid in Healthy Young Adult Males. J Multidiscip Healthc. 2021 Mar 15;14:639-650. doi: 10.2147/JMDH.S290990. eCollection 2021. |
| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided