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eligible carious teeth with exposed pulp by the undergraduate students will be randomly divided into two groups to be treated with direct pulp capping (A), where (A1) represents the comparator group where teeth will be treated with direct application of MTA over the exposed pulp, (A2) represents teeth to be treated with the application of PRF directly over exposed pulp followed by MTA application. clinical and radiographic assessment of tooth vitality, history of pain, pain on percussion, and dentin bridge formation will be performed at baseline, 6 months, and 1 year
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRF along with MTA | Experimental | 5 ml of the participant blood will be drawn into 10 ml test tubes without an anticoagulant and centrifuged immediately .centrifugation will be done using a tabletop centrifuge for 10:12 min at 2700:3000 rounds per minute. The resultant product will exhibit three layers. platelet-poor plasma at the surface, PRF clot in the middle, and red blood cells at the bottom. Sterile tweezers inserted into a test tube to retrieve the PRF clot. The prepared fibrin membrane will be gently packed over the pulp |
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| MTA direct pulp capping | Active Comparator | MTA is primarily calcium oxide in the form of tricalcium silicate, dicalcium silicate and tricalcium aluminate. Bismuth oxide is added for radiopacity, MTA is considered a silicate cement rather than an oxide mixture, a so its biocompatibility is due to its reaction products. MTA elevates the expression of transcription factors, induces dentin bridge formation, possesses biocompatibility9, and sustains a high pH for a longer duration and a close physiochemical seal with dentin that forms an insoluble barrier to prevent microleakag |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| direct pulp capping | Other | teeth with exposed pulp during caries removal will be capped either with PRF followed by mta or mta alone directly on exposed pulp, in both groups restoration will be placed over mta |
| Measure | Description | Time Frame |
|---|---|---|
| clinical success rate | pulp vitality by thermal pulp testing | 6 months |
| clinical success rate | history of pain | 6 months |
| clinical success rate | pain on percussion | 6 months |
| clinical success rate | radiographic signs of pulp necrosis and apical periodontitis | 6 months |
| clinical success rate | pulp vitality by thermal pulp testing | 1 year |
| clinical success rate | history of pain | 1 year |
| clinical success rate | no pain on percussion | 1 year |
| clinical success rate | radiographic signs of pulp necrosis and apical periodontitis | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| radiographic assessment of incidence of regenerative dentin (dentin bridge) | assessment of dentin bridge by digital radiography | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Cairo | Manial | 02 | Egypt |
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