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This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and low-risk oral lesions. Likewise, this study will seek to provide oral cancer-related health education and training on oral-self-examination for beneficiaries
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tobacco use and/or alcohol consumption |
| ||
| No tobacco use and/or alcohol consumption |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention utilised | Other | No intervention utilised |
|
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of machine learning algorithms for predicting high-risk persons | Predictive accuracy of the ML classifiers for forecasting individuals with or likely to develop high-risk lesions within 24 months of first screening encounter based on demographic and lifestyle information. | 24 months |
| Accuracy of machine learning algorithms for discriminating high-risk and low-risk lesions | Predictive accuracy of ML classifiers for classifying high-risk and low-risk lesions based on demographic and lifestyle risk factors, oral high-risk HPV status, and salivary DNA hypermethylation levels. | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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Hong Kong residents aged 45 years and above residing in Southern and Central and Western district council districts (DCD).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| John Adeoye | Contact | 56441784 | jaadeoye@hku.hk |
| Name | Affiliation | Role |
|---|---|---|
| Peter Thomson | The University of Hong Kong | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32450000 | Background | Adeoye J, Choi SW, Thomson P. Bayesian disease mapping and the 'High-Risk' oral cancer population in Hong Kong. J Oral Pathol Med. 2020 Oct;49(9):907-913. doi: 10.1111/jop.13045. Epub 2020 Jun 10. | |
| 32027406 | Background | Adeoye J, Brennan PA, Thomson P. "Search less, verify more"-Reviewing salivary biomarkers in oral cancer detection. J Oral Pathol Med. 2020 Sep;49(8):711-719. doi: 10.1111/jop.13003. Epub 2020 Mar 5. |
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| ID | Term |
|---|---|
| D009062 | Mouth Neoplasms |
| D007972 | Leukoplakia, Oral |
| D009914 | Oral Submucous Fibrosis |
| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009059 | Mouth Diseases |
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Oral rinse samples obtained via drooling in 50cc tubes.
| 32705524 | Background | Adeoye J, Chu CS, Choi SW, Thomson P. Oral Cancer Awareness and Individuals' Inclination to Its Screening and Risk Prediction in Hong Kong. J Cancer Educ. 2022 Apr;37(2):439-448. doi: 10.1007/s13187-020-01834-x. |
| Background | Adeoye J, Thomson P. Strategies to improve diagnosis and risk assessment for oral cancer patients. Faculty Dental Journal. 2020;11(3):122-7. |
| D009057 |
| Stomatognathic Diseases |
| D007971 | Leukoplakia |
| D011230 | Precancerous Conditions |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |