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| Name | Class |
|---|---|
| Centre Hospitalier Universitaire de Brussels, Brussels, Belgium | UNKNOWN |
| Miulli Regional Hospital, Acquaviva delle Fonti, Italy | UNKNOWN |
| University of Foggia | OTHER |
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To assess the prognostic performance of an early global LUS score with respect to the mortality in ICU and duration of ventilation.
This is an international multicenter cohort study on data collected between March and April 2020. The first available lung ultrasound examination that used a 12-regions approach was used to calculate the global LUS score.
Patients are included if they fulfilled the following criteria: 1) admitted to one of the participating ICU; 2) for invasive ventilation; 3) for respiratory failure due to confirmed COVID-19; and 4) having had a LUS examination performed within the first week of start of invasive ventilation.
The primary and secondary outcomes were liberation from invasive ventilation and mortality.
Demographic, clinical and outcome variables will be presented as percentages for categorical variables and as medians with interquartile ranges (IQR) for continuous variables.
Receiver operating characteristics (ROC) analysis will be used to derive the prognostic discriminatory performance of global LUS score in determining succesful extubation and mortality at day 28. The Youden index will be used to derive the optimal cut-off. The association of global LUS with unfavourable outcomes are analyzed with Cox proportional hazard analysis (for successful extubation and alive at day 28), logistic regression models (mortality at day 28). Hazard ratio or odds ratio with 95% confidence intervals were calculated for each outcome.
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| Measure | Description | Time Frame |
|---|---|---|
| Liberation from invasive ventilation | Patient who survived but remained invasively ventilated up to day 28 were marked without event. Patients who survived but were extubated were marked with an event at the day of successful extubation. | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Patient who survived up to day 28 were marked without event. Patients who survived but were extubated were marked with an event at the day of successful extubation. | 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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Severe COVID-19 infection under invasive ventilation who received lung ultrasound examination as a standard care.
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| Name | Affiliation | Role |
|---|---|---|
| Marcus J Schultz, MD | Amsterdam University Medical Centers, location 'AMC' | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Amsterdam | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34662857 | Derived | Pierrakos C, Lieveld A, Pisani L, Smit MR, Heldeweg M, Hagens LA, Smit J, Haaksma M, Veldhuis L, Schmidt RW, Errico G, Marinelli V, Attou R, David CE, Zimatore C, Murgolo F, Grasso S, Mirabella L, Cinnella G, De Bels D, Schultz MJ, Tuinman PR, Bos LD. A Lower Global Lung Ultrasound Score Is Associated with Higher Likelihood of Successful Extubation in Invasively Ventilated COVID-19 Patients. Am J Trop Med Hyg. 2021 Oct 18;105(6):1490-1497. doi: 10.4269/ajtmh.21-0545. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| University of Bari Aldo Moro |
| OTHER |
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| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |