The study aims to explore the difference in outcomes relating to pain and quality of life after open, laparoscopic, and robotic-assisted retromuscular ventral hernia repair.

This is a prospective, multicenter, observational study assessing outcomes relating to pain and quality of life for subjects undergoing open, laparoscopic, or robotic-assisted retromuscular ventral hernia repair. The study will focus on short-term post-operative outcomes through 3 months. The study will also collect recurrence data through 1 year. During the post-operative period through 3 months, pain medication intake, subject reported pain (on post-operative day 7, 14, 21, 28, and 3 months) and quality of life (on day 28, 3 months, and 1 year) and incidence of intra-operative and post-operative adverse events related to the ventral hernia repair will be collected.

Inclusion Criteria:

• Subject is between 18 and 89 years of age
• Subject is a candidate for an elective retromuscular ventral hernia repair under general anesthesia
• Subject has access to complete study assessments electronically and agrees to comply with all follow-up requirements
• Ventral hernia is >= 4cm

Exclusion Criteria:

• Subject who will have an emergent hernia repair
• Subject has a parastomal hernia (i.e. hernia related to ostomy formation)
• Subject with a history of chronic pain and/or taking daily pain medication for >6 weeks
• Subject wtih a history of substance abuse (excluding marijuana) and/or current (within 30 days) narcotic use
• Subject with a history of MRSA infection
• Subject with HbA1c level > 8.5%
• Subject undergoing a minimally invasive (MIS) repair who will require the use of Exparel during the surgical procedure
• Subject who will undergo a concomitant hernia repair or any other concomitant procedure
• Subject has cirrhosis
• Current nicotine use (including vaping) within the past 30 days
• Subject is contraindicated for general anesthesia or surgery
• Subject has a known bleeding or clotting disorder
• Pregnant or suspected pregnancy
• Subject is mentally handicapped or has a psychological disorder or severe systemic illness that would preclude compliance with the study requirements or ability to provide informed consent
• Subject belonging to other vulnerable population, e.g., prisoner or ward of state
• Subject is currently participating in another interventional research study

Subjects who will undergo an elective retromuscular ventral hernia repair procedure and who meet all eligibility criteria will be considered for enrollment.