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The investigators propose to conduct a feasibility study of identifying high-risk ICU patients using previously validated integrated prediction model and employing early palliative care intervention. The study will consist of two four-month time periods: usual care in time period one and usual care plus targeted pro-active palliative care intervention within 48 hours of ICU admission in time period two.
The emerging challenge in critical care medicine focuses on improving patient- and family-centered outcomes. (1) The gold standard for patient-centered care is that which aligns with patients' values, preferences, and goals. (2) Palliative care consultants are known for utilizing shared decision making conversations in the intensive care unit (ICU) in which they elicit patients' values and goals. Accurate prognostic information based on the patient's overall condition sets the context for shared decision-making. With the gravity of the decisions made every day in the ICU, prognostic information is invaluable to patients, families, and clinicians. Historically, prognostic models in the ICU have focused on short-term mortality, such as death prior to hospital discharge, but studies have shown that information about post-ICU quality of life outcomes is important to patients and families as is information about survival for six months or more. Researchers have identified that future work in ICU prognostication must focus on accurately predicting the scope of patient-centered outcomes without losing sight of the higher mortality risk faced by ICU patients and survivors. The investigators propose to perform a proof of concept study based on our previously validated integrated prognostic model to identify medical ICU patients with high risk of mortality in six months and determine the utility of this model in terms of improving quality of life and quality of care. The study will consist of two 4-month time periods: usual care and usual care + targeted pro-active palliative care intervention within 48 hours of ICU admission, respectively. For both phases, the investigators will use the previously validated and published integrated prognostic model consisting of the 'surprise question' of "Would you be surprised if this patient died in the next six months?" with a response of "No", the APACHE IV score, and the Charlson Comorbidity Index (CCI) score to identify ICU patients within 24 hours of their ICU admission with a probability estimate of six-month mortality greater than 40 percent.
Six weeks after ICU discharge, we will contact the legal decision maker for the patient (family member or friend who is the medical power of attorney or healthcare surrogate) regarding their satisfaction with critical care services the patient received during the ICU stay. After obtaining verbal consent, questions will be asked from the modified Family Survey-ICU (FS-ICU) and the global performance measure #18 from the Bereaved Family Survey (BFS). The investigators hypothesize that the systematic identification of ICU patients at highest risk of six-month mortality as a prompt for a targeted pro-active palliative care approach will decrease length of ICU and hospital stay, reduce ICU readmissions, lead to earlier treatment limitation orders according to patients' wishes, and increase family satisfaction with the quality of care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual care | No Intervention | Subjects in the ICU with a poor prognosis will receive usual care in time period one. | |
| Usual care plus palliative care | Experimental | Subjects in the ICU with a poor prognosis will receive usual care plus targeted pro-active palliative care intervention within 48 hours of ICU admission in time period two. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pro-active palliative care | Other | Patient with high risk of mortality in ICU will be identified using our previously validated prognostic model. Intervention phase will employ pro-active palliative care on eligible patients after they survive 48 hours in ICU. |
| Measure | Description | Time Frame |
|---|---|---|
| Length Of Stay (LOS) in the medical ICU | Number of days subject was admitted to the medical ICU | From enrollment to Discharge from the ICU, an average of 24 weeks |
| Length Of Stay in hospital | Number of total days subject was hospitalized | From enrollment to Discharge from the hospital, an average of 24 weeks |
| Medical ICU re-admission during the hospital stay | Number of times a patient was re-admitted to the medical ICU | From enrollment to discharge from the hospital, up to 16 weeks |
| Treatment limitation orders within 48 hours of admission | Count of subjects that had or completed any treatment limitation orders (do-not-resuscitate, do-not-intubate, no vasopressors, etc) within 48 hours of admission | From enrollment to discharge from the hospital, an average of 24 weeks |
| Family satisfaction with care in ICU | Six-weeks post discharge, a telephone survey will be conducted with health care surrogate or medical power attorney to determine their satisfaction with the care received in ICU. 5 point scale with 1= very dissatisfied and 5= Completely Satisfied | From enrollment to six weeks post ICU discharge |
| Advance directive completion | Difference in completion rate of advance directives [a written statement of a person's wishes regarding medical treatment] between the baseline period (Standard of Care Patients) and following the intervention (Early Palliative Care Patients) | From enrollment to hospital discharge, an average of 24 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West Virginia University Hospital | Morgantown | West Virginia | 26506 | United States |
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Pre and post phase study evaluating the utility of pro-active palliative care in high risk ICU patients identified using integrated prediction model
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| Physician Orders for Scope of Treatment (POST) form completion | Difference in completion rate of the Physician Orders for scope of Treatment (POST) form between the baseline period (Standard of Care Patients) and following the intervention (Early Palliative Care Patients) | From enrollment to hospital discharge, an average of 24 weeks |
| Discharge Outcome Location-Home | Difference in discharge outcome location from the baseline period (Standard of Care Patients) and following the intervention (Early Palliative Care Patients) | From enrollment to six weeks post ICU discharge |
| Discharge Outcome Location-Skilled Nursing Facility | Difference in discharge outcome location from the baseline period (Standard of Care Patients) and following the intervention (Early Palliative Care Patients) | From enrollment to six weeks post ICU discharge |
| Discharge Outcome Location-LTACH | Difference in discharge outcome location from the baseline period (Standard of Care Patients) and following the intervention (Early Palliative Care Patients) | From enrollment to six weeks post ICU discharge |
| Discharge outcomes-Death | Difference in discharge outcome location from the baseline period (Standard of Care Patients) and following the intervention (Early Palliative Care Patients) | From enrollment to six weeks post ICU discharge |
| Site of death-ICU | Count of subjects that passed in specific locations. | From enrollment to six weeks post ICU discharge |
| Site of death-Hospital | Count of subjects that passed in specific locations. | From enrollment to six weeks post ICU discharge |
| Site of death-Home | Count of subjects that passed in specific locations. | From enrollment to six weeks post ICU discharge |
| Site of death-Hospice | Count of subjects that passed in specific locations. | From enrollment to six weeks post ICU discharge |
| Site of death-Skilled Nursing Facility | Count of subjects that passed in specific locations. | From enrollment to six weeks post ICU discharge |