Botulinum Toxin Injection in Patients Undergoing Hemorrhoidectomy-A Prospective, Randomized Study

The Optimal Timing of Botulinum Toxin Injection for Pain Control in Patients Undergoing Hemorrhoidectomy-A Prospective, Randomized Study

This is a prospective, randomized study, which anticipatedly recruited 60 patients in the outpatient department who need hemorrhoidectomy from January 2019 to December 2019. After obtaining those patients' consent in the clinic, they were randomly assigned to two groups at a 1:1 ratio using a computer-generated list of random numbers (Microsoft Excel). One group received Botulinum toxin injection during the outpatient clinic one week before the operation(experimental group, EG), and the other group received injection during the operation(control group, CG). The two groups were compared for the influence of postoperative pain control and wound healing rate.

Inclusion Criteria:

• patients with age over 20 but under 80, who need to undergo hemorrhoidectomy

Exclusion Criteria:

• patients under the age of 20
• patients with nonsteroidal anti-inflammatory drugs (NSAIDs) allergy or sensitivity
• patients with Botulinum toxin allergy or sensitivity
• patients with dialysis or renal insufficiency
• pregnant and breastfeeding women
• vulnerable population