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| Name | Class |
|---|---|
| Belarusian State Medical University | OTHER |
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Treatment of patients with inflammatory-dystrophic diseases of the cornea using autologous limbal stem cells (corneal epithelial stem cells) or adipose-derived mesenchymal stem cells
In order to treat inflammatory and dystrophic diseases of the cornea perilimbal injections of cultured autologous stem cells are performed. Corneal (limbal) epithelial stem cells (LSC) or mesenchymal stem cells derived from adipose tissue (ADSC) are mixed with sodium hyaluronate 1%
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mesenchymal stem cells | Experimental | Patients with inflammatory-dystrophic diseases of the cornea receiving standard treatment plus adipose-derived mesenchymal stem cells |
|
| limbal stem cells | Experimental | Patients with inflammatory-dystrophic diseases of the cornea receiving standard treatment plus adipose-derived limbal stem cells |
|
| control | Active Comparator | Patients with inflammatory-dystrophic diseases of the cornea receiving standard treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mesenchymal stem cells | Biological | Autologous adipose-derived mesenchymal stem cells mixed with sodium hyaluronate 1% solution |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of cured patients | Number of patients cured | 2 month |
| Number of patients with treatment-related adverse events | MSC/LSC application related adverse events assessed by blood count, liver and function tests | 4 weeks |
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Inclusion Criteria:
inflammatory-dystrophic diseases of the cornea:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Igor Volotovski, Prof | Head of the Lab of Institute of Biophysics and Cell Engineering | Study Director |
| Liudmila Marchenko, Prof | Head of the Department of eyes diseases of Belarusian State Medical University | Study Director |
| Zinaida Kvacheva | Leading researcher, Institute of Biophysics and Cell Engineering | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | Minsk | 220072 | Belarus |
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| limbal stem cells | Biological | Autologous adipose-derived limbal stem cells mixed with sodium hyaluronate 1% solution |
|
| standard treatment | Other | Standard treatment according to the Clinical protocols |
|
| ID | Term |
|---|---|
| D003320 | Corneal Ulcer |
| D003316 | Corneal Diseases |
| D003317 | Corneal Dystrophies, Hereditary |
| ID | Term |
|---|---|
| D015817 | Eye Infections |
| D007239 | Infections |
| D007634 | Keratitis |
| D005128 | Eye Diseases |
| D015785 | Eye Diseases, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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