Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology | OTHER_GOV |
Not provided
Not provided
Not provided
Not provided
Treatment of patients with non-healing wounds and trophic ulcers using local LED phototherapy with local transplantation of autologous dermal fibroblasts
During the implementation of the project, it was planned to develop a method for the treatment of trophic ulcers using injection of autologous dermal fibroblasts in the wound.
The positive outlook for the effectiveness of photodiode therapy with dermal fibroblasts is due to the following:
Twelve patients were included in the study. Dermal fibroblasts were isolated from the skin patients, cultured and then transplanted back to the wound.
The therapeutic dose of cells was 50k per cm2 of the wound area. Follow up patients monitoring was performed at 1, 2 and more months after injection.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients treated with dermal fibroblasts | Experimental | Cultured dermal fibroblasts and LED phototherepy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dermal fibroblasts | Biological | Cultured autologous dermal fibroblasts. For PR: The name "dermal fibroblasts" is exactly the name of the cell product registered by our ministry of health. There is no trade or international name. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with tropic ulcers cured | Number of patients cured | 1 month |
| Number of patients with treatment-related adverse events | Fibroblasts injection related adverse events assessed by blood count and function tests | 4 weeks |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Igor Volotovski, Prof | Head of the Lab of Institute of Biophysics and Cell Engineering | Study Director |
| Stanislav Tretyak, Prof | Head of 2nd Department of Surgical Diseases of BSMU | Study Director |
| Evgeny Baranov, Dr | Ass prof of 2nd Department of Surgical Diseases of BSMU | Principal Investigator |
| Zinaida Kvacheva, Dr | Lead Researcher of Institute of Biophysics and Cell Engineering | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | Minsk | 220072 | Belarus |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| LED phototherapy | Device | LED phototherapy |
|