Precision medicine is to achieve individual optimal health care, given the biological mechanisms, genetic variants, and environmental measurements. Take mood disorder (MD) as an example, we aim to develop systems and precision medicine in Taiwanese population.

MD is a very serious and dysfunctional mental disorder. Since MD patients with treatment have high risk of neurocognitive impairment and metabolic disturbances, the therapeutic strategies are of clinical importance. Individual difference of treatment outcome in MD patients would result from genetic variants, environmental factors, and their interactions. Also, the treatment outcome of MD contains multiple dimensions, including improvement of disease severity, neurocognitive function, and optimized medication strategy. However, comprehensive development of approaches to investigate the multiple dimensions of treatment outcome in MD patients is limited. In this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.

Inclusion Criteria:

• Male or female patients, 20- 70 years of age
• Major depression disorder who met the DSM-V diagnostic criteria were enrolled
• Subjects take at least one kind of antidepressant.

Exclusion Criteria:

• Pregnant or breast-feeding
• Presence of any other major psychiatric illness
• History of substance and alcohol abuse or dependence
• Presence of auto-immune disorder and infectious diseases

Subjects who met the criteria will be successively recruited from the National Cheng Kung University Hospital.