Meclizine Plasma Levels in Responders and Non-responders

Meclizine Plasma Levels in Responders and Non-responders

Motion sickness is a debilitating condition that can effect many crew members. Meclizine has long been known as an effective anti motion sickness drug. The response to the drug is variable - some are responders, while others are resistant to the drug. The aim of the present study is to examine whether there is a correlation between meclizine plasma levels and clinical response.

Inclusion Criteria:

• Seasickness questioner (WIKER) score of 7.
• Subjective functioning at 1 meter sea voyage - 5/10 and lower.
• Subjects who were prescribed 25mg of meclizine.
• Subjects who did not take any other drugs 48 prior to their participation in the study.

Exclusion Criteria:

• Known hearing loss or any vestibular impairment
• Vertigo complains
• Any ear infection
• Use of Scopolamine based anti-seasickness drugs.
• Use of meclizine 50mg.