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This echocardiography study will characterize heart structure and function during labor. Imaging of the heart during the stress of labor could increase detection of subclinical cardiovascular disease using advanced imaging techniques. Cardiac serum biomarkers and complication rates will also be measured and compared between patients with and without evidence of cardiovascular disease on echocardiography.
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| Measure | Description | Time Frame |
|---|---|---|
| The proportion of patients with an abnormal strain pattern as compared to parturients not in labor | Left ventricular strain | During echocardiogram procedure |
| The proportion of patients with diastolic dysfunction as compared to parturients not in labor | Abnormal diastolic function | During echocardiogram procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Estimated right ventricular systolic pressure | Comparing estimated right ventricular systolic pressure between patients in active labor as compared to those who are not in active labor (mm Hg) | During echocardiogram procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular systolic function | Simpson's method of discs motion abnormalities and diastolic function | During echocardiogram procedure |
| Left ventricular myocardial performance index | During echocardiogram procedure |
Inclusion Criteria:
Exclusion Criteria:
Any pregnant patient, even if gender identity is male.
Healthy women between 18 and 35 years of age with singleton pregnancy in active labor
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03766 | United States |
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| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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Serum
| Total number of patients with the presence of regional wall motion abnormalities | During echocardiogram procedure |
| Total number of patients with abnormal global right ventricular dysfunction | During echocardiogram procedure |
| Right ventricular strain | % | During echocardiogram procedure |
| Tricuspid annular plane systolic excursion | centimeters | During echocardiogram procedure |
| Tissue doppler s' | cm/sec | During echocardiogram procedure |
| Total number of maternal deaths within 0-42 days post-partum | 0 to 42 days post-partum |
| The number of patients with an identifiable Centers for Disease Control Severe Maternal Morbidity Identification complication post-partum | Acute myocardial infarction, aortic aneurysm, acute renal failure, adult respiratory distress syndrome, amniotic fluid embolism, cardiac arrest, ventricular fibrillation, conversion of cardiac rhythm, disseminated intravascular coagulation, eclampsia, heart failure, arrest during surgery or procedure, puerperal cerebrovascular disorders, pulmonary edema, aspiration, cardiopulmonary anesthesia complications, sepsis, shock, air or thrombotic embolism, blood product transfusion, hysterectomy, temporary tracheostomy, requiring ventilation | 0 to 42 days post-partum |
| The number of patients with a pulse oximetry reading <90% after delivery | 0 to 42 days post-partum |
| The number of patients who required oxygen administration after delivery | 0 to 42 days post-partum |
| The number of patients who develop atrial fibrillation or premature atrial complexes | 0 to 42 days post-partum |
| The number of patients who develop a stroke | Stroke must be verified by imaging including either computed tomography or magnetic resonance imaging. | 0 to 42 days post-partum |
| The number of patients with an elevation in transaminase levels during labor or after delivery | 0 to 42 days post-partum |
| Hospital length of stay | Total hours from admission to discharge | 0 to 42 days post-partum |
| The number of patients requiring intensive care unit admission within 42 days post delivery | 0 to 42 days post-partum |
| Mortality within 42 days post delivery | 0 to 42 days post-partum |
| The number of patients with a post-partum diagnosis of post-partum hemorrhage | 0 to 42 days post-partum |
| The total number of patients who require additional uterotonic medications other than oxytocin after delivery | Medications include additional dosage of oxytocin above 3 units, methylergonovine, carboprost, tranexamic acid or misoprostol | 0 to 42 days post-partum |
| The number of patients requiring a transfusion | Cell Saver, red blood cells, platelets, fresh frozen plasma, cryoprecipitate | 0 to 42 days post-partum |
| Blood loss | Estimated and quantitated blood loss as well as the difference between pre-delivery hemoglobin and post-delivery lowest hemoglobin during admission | 0 to 42 days post-partum |
| Number of patients requiring vasopressor after delivery to support blood pressure | phenylephrine, ephedrine, norepinephrine, epinephrine, vasopressin, inhaled nitrous oxide, inhaled epoprostenol | 0 to 42 days post-partum |
| Activin A level | Less than 3 hours after echocardiogram procedure |
| Placental Growth Factor | Less than 3 hours after echocardiogram procedure |
| Soluble endoglin | Less than 3 hours after echocardiogram procedure |