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This study will include the placement of a pressure volume (PV) loop catheter in the right atrium of patients undergoing left ventricular assist device (LVAD) placement and measure relevant PV loop data. Transesophageal echocardiography (TEE) and pulmonary artery (PA) catheter parameters as comparators to the PV loop will be recorded.
This will be a prospective observational study design to characterize right ventricular function in 5 consecutive patients undergoing LVAD implantation at the University of Minnesota Medical Center (UMMC). Pre-, intra- and postoperative care delivery to all enrolled and consented patients will meet the standards of care otherwise delivered to patients undergoing LVAD implantation at UMMC; care delivery will be at the discretion of the clinical care team and will not be altered based on the output of the right ventricular high-fidelity conductance catheters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational Group | Characterize right ventricular function while undergoing LVAD implantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hemodynamic assessment | Diagnostic Test | Hemodynamic assessment of the right ventricle using pressure-volume loop catheter and pulmonary artery catheter |
|
| Measure | Description | Time Frame |
|---|---|---|
| Stroke volume | Stroke volume will be reported in units of millilitres per square metre | Approximately 4-6 hours |
| Heart rate | Heart rate will be reported in units of beats per minute | Approximately 4-6 hours |
| Ejection fraction | Ejection fraction will be reported as a percent | Approximately 4-6 hours |
| Cardiac output | Cardiac output will be reported in units of milliliters per minute | Approximately 4-6 hours |
| End-systolic pressure | End-systolic pressure will be reported in units of mmHG | Approximately 4-6 hours |
| End-systolic volume | End-systolic volume will be reported in units of milliliters | Approximately 4-6 hours |
| End-diastolic pressure | End-diastolic pressure will be reported in units of mmHG | Approximately 4-6 hours |
| End-diastolic volume | End-diastolic volume will be reported in units of milliliters | Approximately 4-6 hours |
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Inclusion Criteria:
- Patients undergoing left ventricular assist device (LVAD) placement at the University of Minnesota Medical Center
Exclusion Criteria:
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All consecutive patients 18 years or older undergoing left ventricular assist device (LVAD) placement at the University of Minnesota Medical Center
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| Name | Affiliation | Role |
|---|---|---|
| Tjorvi Perry, MD, MMSc | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
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| Right ventricular dP/dt | Right ventricular dP/dt will be reported in units of mmHg per second | Approximately 4-6 hours |
| Stroke work | Stroke work will be reported in units of gram meters (g*m) | Approximately 4-6 hours |
| ID | Term |
|---|---|
| D018497 | Ventricular Dysfunction, Right |
| ID | Term |
|---|---|
| D018754 | Ventricular Dysfunction |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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