In this study, meningioma organoids will be established from patients' tissues and the characterization of the organoid will be performed.

Aims and Hypothesis to be tested:

The investigators hypothesized that the derived organoid should have a similar morphological and genetic mutation signatures to the patient primary tissue.

Study period: 1 year for patient recruitment and organoid generation from patient tumor

Study population: 30

Study samples:

Patient's meningioma tumor sample are collected from patients with surgical needs. Sample collected are used for organoid culture. Morphological and genetic characteristics will be compared between the patient tumor sample and the corresponding derived organoids

Primary outcome measures:

Whole exome sequencing data of patient tumor tissue and patients-derived organoids

Inclusion Criteria:

1. Adult patients (aged >18 years) with meningioma
2. Admission into Prince Wales hospitals neurosurgical services
3. Patients with surgical needs of meningioma removal

Exclusion Criteria:

1. Patients (or next-of-kin as appropriate) refuse to participate into the study

Patients with meningioma admitted to Prince Wales Hospitals neurosurgical services