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| Name | Class |
|---|---|
| Medical Action Myanmar | OTHER |
| Shoklo Malaria Research Unit | OTHER |
| Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit | OTHER |
| Building Resources Across Communities (BRAC), Bangladesh |
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The study will collect information to understand the causes and outcomes of febrile illness in rural areas in countries across South and Southeast Asia ( including Cambodia, Laos, Myanmar and Bangladesh). The findings will be used to identify new tests and treatments that can improve the management of febrile patients in the future.
This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z
This study aims to better understand and quantify the burden of febrile illness, the aetiological causes and the manner in which it affects the people living in rural areas in South and Southeast Asia, all on a scale which has not been attempted before. The SEACTN RFI project will collect information to help better understand and predict these outcomes based on a multitude of factors, which will form the basis for interventions within the network in the future. Determining the incidence, causes and outcomes of febrile illness in these settings will be done through two work packages. The first of these, Work Package A (WP-A), the subject of this study, will be carried out at the community level, primarily by engaging village health worker (VHWs) and low-level Health Centres (HCs) which serve the communities to recruit patients presenting with a febrile illness. These patients will be assessed for presenting symptoms and followed up for clinical outcomes. Collection of specimen for diagnostic investigations in these settings is challenging. Currently, mRDTs are conducted by VHWs and HCs in these networks, therefore by using the same process, but also applying blood to filter paper and allowing it to dry (DBS), investigators will test for certain other pathogens, which will increase the aetiological yield.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with febrile illness | Participants from approximately 650 villages, with a target number of 100,000 episodes of febrile illness, will be enrolled into this study. |
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| Measure | Description | Time Frame |
|---|---|---|
| Local incidence of febrile illness | The incidence per year that an individual seeks care for a febrile illness with the village health workers or local health facility, at the village level. | From Months 0 to 24 |
| Overall incidence of febrile illness | The incidence per year that an individual seeks care for a febrile illness with the village health workers or local health facility, at the regional level. These estimates will later be triangulated with and extrapolated from using health seeking behavior surveys for an estimate of the total incidence of febrile illness. | From Months 0 to 24 |
| Mortality | Case fatality rates in febrile illness | Within approximately 1 month of first presentation to the village health worker or health facility |
| Morbidity | Duration of illness in patients presenting with a fever to the village health worker or health facility. | Over 1 month after first presentation |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of pathogens in febrile patients | Pathogens will be detected in patients presenting over a 24 month period using point of care tests and diagnostic assays on acute and convalescent dried blood spots. | Samples collected over approximately 24 months |
| The correlation between host biomarker concentrations, aetiological diagnoses and clinical outcomes. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with an acute febrile illness of all ages presenting to village health workers (VHWs) or peripheral health facilities.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yoel Lubell, Prof. | Contact | +66-857201350 | yoel@tropmedres.ac |
| Name | Affiliation | Role |
|---|---|---|
| Yoel Lubell, Prof | Mahidol Oxford Tropical Medicine Research Unit | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Building Resources Across Communities (BRAC) | Recruiting | Dhaka | 1212 | Bangladesh |
Data collected for this study will be under the custodianship of MORU. With participant's consent, data from this study may be shared in a de-identified form with other groups or researchers in accordance with the MORU Data Sharing Policy.
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After completion of trial activities and reporting
MORU Data Sharing Policy. (http://www.tropmedres.ac/data-sharing-policy)
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| Mahidol Oxford Tropical Medicine Research Unit | OTHER |
| Action for Health Development (AHEAD) | UNKNOWN |
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Dried blood spots (DBS)
The area under the curve, sensitivity and specificity of host biomarkers to identify bacterial infections and to predict severe outcomes. |
| Samples collected over approximately 24 months |
| Medical Action Myanmar (MAM) | Not yet recruiting | Yangon | 11201 | Burma |
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| Action for Health Development (AHEAD) | Recruiting | Battambang | Cambodia |
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| Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU) | Recruiting | Vientiane | Vientiane Prefecture | 01000 | Laos |
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| Mahidol VivaResearch Unit, Faculty of Tropical Medicine, Mahidol University (MVRU) | Recruiting | Ratchathewi | Bangkok | 10400 | Thailand |
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| Shoklo Malaria Research Unit (SMRU) | Recruiting | Mae Sot | Changwat Tak | 63110 | Thailand |
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| Chiangrai Clinical Research Unit (CCRU) | Recruiting | Chiang Rai | 57000 | Thailand |
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