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| Name | Class |
|---|---|
| Fraunhofer Institute for Ceramic Technologies and Systems IKTS | UNKNOWN |
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The purpose of this study is the investigation of biomechanical properties of the cornea using computer-aided data analysis. Currently, it is known that keratoconus and glaucoma are ocular disease that are associated with biomechanical alterations of the cornea. Corneal ectasia, especially keratoconus, is a corneal disease that leads to an irreversible loss of visual acuity while the cornea becomes steeper, thinner and irregular. For these patients, surgical intervention (e.g. corneal cross-linking) is performed, in case of disease progression. In glaucoma, the information about corneal alterations serves in two ways, first, correct measurement of intra ocular pressure (IOP); second, early diagnosis of suspects before visual field defects are detectable.
Especially, the Corvis ST is an air-puff tonometer that measures intraocular pressure, corneal thickness (CCT) as well as dynamic corneal response (DCR) parameters. Most of the DCR parameters are affected by IOP and CCT: Therefore, algorithm are needed to determine parameters without impact of IOP and CCT that are describe the biomechanical properties of the cornea.
In this study, an eye twin based on finite element modeling is used to measure advanced properties of corneal biomechanics. Raw data of Corvis ST measurement are exported from the device and imported into the model. The outcome of these calculations are merged together and are compared to further clinical findings (e. g. corneal topography and tomography, axial eye length).
Further information were obtained:
Age, sex, refraction, family history, known duration of disease, previous ocular surgery, systemic diseases, systemic and topical medication; biomicroscopy, anterior optical coherence tomography (OCT), Scheimpflug-based tomography (Pentacam), Biomechanical assessment (Ocular Response Analyzer and Corneal Visualization with the Scheimpflug Technology), optical biometry, confocal microscopy, endothelium cell count.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy | Healthy eyes without any signs of ocular diseases |
| |
| Ectasia | ectasia suspects early, moderate and advanced keratoconus |
| |
| Glaucoma | Normal Tension glaucoma Primary Open-Angle Glaucoma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Corneal biomechanics (Corvis ST, Oculus, Wetzlar, Germany) | Diagnostic Test | To measure corneal biomechanics with Scheimpflug based tonometry |
|
| Measure | Description | Time Frame |
|---|---|---|
| New biomechanical parameters of the cornea | To detemine biomechanical alterations in different ocular diseases and correlate them with other clinical findings | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Dependence of new biomechanical Parameters of the cornea from influencing factors | e. g. corneal thickness, intraocular pressure | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with corneal ectasia or glaucoma. Healthy eyes that matching to ocular disease groups concerning age.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology; Medical Faculty Carl Gustav Carus; Technical University Dresden | Dresden | Saxony | 01307 | Germany |
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| Corneal topography and tomography (Pentacam, Oculus, Wetzlar, Germany) | Diagnostic Test | To measure corneal topography and tomography with Scheimpflug tomograph |
|
| Optic nerve head measurement | Diagnostic Test | To measure optic nerve excavation |
|
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D001251 | Astigmatism |
| D007640 | Keratoconus |
| D005901 | Glaucoma |
| D005902 | Glaucoma, Open-Angle |
| D057066 | Low Tension Glaucoma |
| D004108 | Dilatation, Pathologic |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D012030 | Refractive Errors |
| D009798 | Ocular Hypertension |
| D009901 | Optic Nerve Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014785 | Vision, Ocular |
| D019781 | Corneal Topography |
| D014054 | Tomography |
| ID | Term |
|---|---|
| D055537 | Light Signal Transduction |
| D015398 | Signal Transduction |
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D002468 | Cell Physiological Phenomena |
| D012677 | Sensation |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D009799 | Ocular Physiological Phenomena |
| D003941 | Diagnostic Techniques, Ophthalmological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003952 | Diagnostic Imaging |
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