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Echography guided percutaneous neuromodulation is a physical therapy technique, whose main objective is the treatment of pain with direct stimulation of the peripheral nerves using a rome needle of acupuncture as an active electrode for applying currents of electrostimulation.
The neurophysiological basis and the effects on the sensory and motor systems of this technique are not characterised. The present study proposes to perform the intervention on the area adjacent to the median nerve and to apply different stimulation protocols on healthy subjects to answer those questions.
Intervention is going to be performed in the medial side of the arm, where the median nerve is accessible to the intervention. The theoretical basis of the technique is to produce specific controlled changes in the somatosensory system using synaptic plasticity, to ultimate affect the perception of pain through reduction of nociception afference. Subsequently, the protocols are based on synaptic physiology and the circuitry of the somatosensory system.
The protocols are the following:
The study design is an experimental clinical trial, with randomized order of intervention with repeated measurements. This means each subject is having the three protocols at randomized order, with a gap of at least two weeks between them. The study is triple-blinded.
Somatomotor system variables, as sensory and pain pressure thresholds, grip strength, surface electromyographic activity and blood flow are evaluated on the hand of the subject. The arm to treat was also randomized for each subject The measurements are pre-intervention, post-intervention and 24 hours after the intervention for each protocol. Blood flow are measured only pre-intervention and post-intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low-frequency and high-intensity | Experimental | The intervention of ultrasound guided percutaneous neuromodulation is applied over the median nerve. The parameters are continuous stimulation of low frequency (2 hz) and high intensity (slightly painful) during 16 minutes. |
|
| High-frequency and low-intensity | Experimental | The intervention of ultrasound guided percutaneous neuromodulation is applied over the median nerve. The parameters are high frequency (100 hz) and low intensity trains. There are 5 trains, 5 second active current and 55 second without current per train. The current is off on the first 11 minutes and the next 5 minutes it will be on. The total time is 16 minutes. |
|
| Control group | Sham Comparator | The intervention of ultrasound guided percutaneous neuromodulation is applied over the median nerve without current during 16 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound guided percutaneous neuromodulation | Other | It is a technique that consists in the electrical stimulation of peripheral nerve trunks, inserting an acupuncture needle in its path and using it as an electrode to apply electrical current |
| Measure | Description | Time Frame |
|---|---|---|
| Mechanical Threshold elicited with Von Frey Filaments | We use Von Frey Filaments of increasing caliber to make pression in the evaluated areas. When the test subject reports perception of mechanical sensation, that caliber is considered the pressure threshold to elicit mechanical. The test is performed with subject's eyes closed | Pre-intervention / baseline |
| Mechanical Threshold elicited with Von Frey Filaments | We use Von Frey Filaments of increasing caliber to make pression in the evaluated areas. When the test subject reports perception of mechanical sensation, that caliber is considered the pressure threshold to elicit mechanical. The test is performed with subject's eyes closed. | Immediately after the intervention |
| Mechanical Threshold elicited with Von Frey Filaments | We use Von Frey Filaments of increasing caliber to make pression in the evaluated areas. When the test subject reports perception of mechanical sensation, that caliber is considered the pressure threshold to elicit mechanical. The test is performed with subject's eyes closed. | 24 hours after the intervention |
| Pinprick pain threshold elicited with Von Frey Filaments | We use Von Frey Filaments of increasing caliber to make pression in the evaluated areas. When the test subject reports perception of pinprick sensation, that caliber is considered the pressure threshold to elicit pinprick pain. The test is performed with subject's eyes closed | pre-intervention / baseline |
| Pinprick pain threshold elicited with Von Frey Filaments | We use Von Frey Filaments of increasing caliber to make pression in the evaluated areas. When the test subject reports perception of pinprick sensation, that caliber is considered the pressure threshold to elicit pinprick pain. The test is performed with subject's eyes closed |
| Measure | Description | Time Frame |
|---|---|---|
| Electric current threshold of perception with low frequency | Using the intervention needle as an active electrode. The parameters are 2 hz and 150 msec of pulse duration and the intensity was increased progressively. When the subject experienced any sense of pain, sensitivity and muscle contraction in the needle and arm, he/she must tell it and the threshold is annotated. | pre-intervention / baseline |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Patricia Beltrá López | Clínica Francisco Javier Ortega Puebla | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clínica Francisco Ortega Rehabilitación Avanzada, S.L. | Elche | Alicante | 03203 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24512114 | Background | Wilson RD, Harris MA, Gunzler DD, Bennett ME, Chae J. Percutaneous peripheral nerve stimulation for chronic pain in subacromial impingement syndrome: a case series. Neuromodulation. 2014 Dec;17(8):771-6; discussion 776. doi: 10.1111/ner.12152. Epub 2014 Feb 11. | |
| 19238503 | Background | Toprak U, Selvi NA, Ates A, Erhuner Z, Bostanoglu S, Karademir MA, Karaaslan Y. Dynamic Doppler evaluation of the hand arteries of the patients with Raynaud's disease. Clin Rheumatol. 2009 Jun;28(6):679-83. doi: 10.1007/s10067-009-1131-1. Epub 2009 Feb 24. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Randomized intervention of repeated measures, quadruple-blinded
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Order of treatments was randomized by a third person not involved in any of the other phases. Also, after the care provider has inserted the needle in the three groups, another third person without involvement in any other phase of the study choose the assigned treatment between three pre-programmed closed set of parameters in the stimulation machine, thus leaving treatment unknown for the care provider, the participant, the investigator and the outcome assessor, which received only encoded names for the groups.
| Immediately after the intervention |
| Pinprick pain threshold elicited with Von Frey Filaments | We use Von Frey Filaments of increasing caliber to make pression in the evaluated areas. When the test subject reports perception of pinprick sensation, that caliber is considered the pressure threshold to elicit pinprick pain. The test is performed with subject's eyes closed | 24 hours after the intervention |
| Pain evocated with Von Frey Filaments. | We use Von Frey Filaments of increasing caliber to make pression with 100g, 180g and 300g in the evaluated areas. Each filament to make pression three times. The subject reports the pain in a scale of 0-10 number (scale NSR: 0 is any pain and 10 is the maximal perception of pain. The test is performed with subject's eyes closed. | Pre-intervention / baseline |
| Pain evocated with Von Frey Filaments. | We use Von Frey Filaments of increasing caliber to make pression with 100g, 180g and 300g in the evaluated areas. Each filament to make pression three times. The subject reports the pain in a scale of 0-10 number (scale NSR: 0 is any pain and 10 is the maximal perception of pain. The test is performed with subject's eyes closed. | Immediately after the intervention |
| Pain evocated with Von Frey Filaments. | We use Von Frey Filaments of increasing caliber to make pression with 100g, 180g and 300g in the evaluated areas. Each filament to make pression three times. The subject reports the pain in a scale of 0-10 number (scale NSR: 0 is any pain and 10 is the maximal perception of pain. The test is performed with subject's eyes closed. | 24 hours after the intervention |
| Pressure pain threshold with algometer. | On the marked areas we make pressure with pressure algometer. When the subject experiences any sense of pain, he/she has to say "stop" and immediately the algometer was removed. The number in Kg marked by the algometer is annotated. The mean of two measurements was taken for analysis. The second measurement was taken with a minimum of 30 seconds after the previous one. | pre-intervention / baseline |
| Change in pressure pain threshold with algometer. | On the marked areas we make pressure with pressure algometer. When the subject experiences any sense of pain, he/she has to say "stop" and immediately the algometer was removed. The number in Kg marked by the algometer is annotated. The mean of two measurements was taken for analysis. The second measurement was taken with a minimum of 30 seconds after the previous one. | Immediately after the intervention |
| Change in pressure pain threshold with algometer. | On the marked areas we make pressure with pressure algometer. When the subject experiences any sense of pain, he/she has to say "stop" and immediately the algometer was removed. The number in Kg marked by the algometer is annotated. The mean of two measurements was taken for analysis. The second measurement was taken with a minimum of 30 seconds after the previous one. | 24 hours after the intervention |
| Maximum grip force with dynamometer | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during 5 second, 3 times with 30 seconds to rest between them. | pre-intervention / baseline |
| Change in maximum grip force with dynamometer | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during 5 second, 3 times with 30 seconds to rest between them. | Immediately after the intervention |
| Change in maximum grip force with dynamometer. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during 5 second, 3 times with 30 seconds to rest between them. | 24 hours after the intervention |
| Maximum grip force with surface electromyography. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during 5 second, 3 times with 30 seconds to rest between them. | pre-intervention / baseline |
| Change in maximum grip force with surface electromyography. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during 5 second, 3 times with 30 seconds to rest between them. | Immediately after the intervention |
| Change in maximum grip force with surface electromyography. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during 5 second, 3 times with 30 seconds to rest between them. | 24 hours after the intervention |
| Arterial peak systolic velocity with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial peak systolic during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial peak systolic velocity with Color Doppler Ultrasonography in placebo group | In placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial peak systolic during 5 cardiac cycles inmediately after introduce the needly in the arm. | Immediately after the needle insertion |
| Change in arterial peak systolic velocity with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial peak systolic during 5 cardiac cycles. | Immediately after the intervention |
| Arterial volume flow with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial volume flow during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial volume flow with Color Doppler Ultrasonography | In placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial volume flow during 5 cardiac cycles. | Immediately after the needle insertion |
| Change in arterial volume flow with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial volume flow during 5 cardiac cycles. | Immediately after the intervention |
| Change in Electric current threshold of perception with low frequency | Using the intervention needle as an active electrode. The parameters are 2 hz and 150 msec of pulse duration and the intensity was increased progressively. When the subject experienced any sense of pain, sensitivity and muscle contraction in the needle and arm, he/she must tell it and the threshold is annotated. | Immediately after the intervention |
| Change in Electric current threshold of perception with low frequency | Using the intervention needle as an active electrode. The parameters are 2 hz and 150 msec of pulse duration and the intensity was increased progressively. When the subject experienced any sense of pain, sensitivity and muscle contraction in the needle and arm, he/she must tell it and the threshold is annotated. | 24 hours after the intervention |
| Electric current threshold of perception with high frequency | Using the intervention needle as an active electrode. The parameters are 100 hz and 150 msec of pulse duration and the intensity was increased progressively. When the subject experienced any sense of pain, sensitivity and muscle contraction in the needle and arm, he/she must tell it and the threshold is annotated. | pre-intervention / baseline |
| Change electric current threshold of perception with high frequency | Using the intervention needle as an active electrode. The parameters are 100 hz and 150 msec of pulse duration and the intensity was increased progressively. When the subject experienced any sense of pain, sensitivity and muscle contraction in the needle and arm, he/she must tell it and the threshold is annotated. | Immediately after the intervention |
| Change electric current threshold of perception with high frequency | Using the intervention needle as an active electrode. The parameters are 100 hz and 150 msec of pulse duration and the intensity was increased progressively. When the subject experienced any sense of pain, sensitivity and muscle contraction in the needle and arm, he/she must tell it and the threshold is annotated. | 24 hours after the intervention |
| Force grip resistance with dynamometer | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during one minute trying to maintain maximal force. | Pre-intervention / Baseline |
| Change in Force grip resistance with dynamometer. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during one minute trying to maintain maximal force. | Immediately after the intervention |
| Change in Force grip resistance with dynamometer. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during one minute trying to maintain maximal force. | 24 hours after the intervention |
| Force grip resistance with surface electromyography. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during one minute trying to maintain maximal force. | Pre-intervention / Baseline |
| Change in Force grip resistance with surface electromyography. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during one minute trying to maintain maximal force. | Immediately after the intervention |
| Change in Force grip resistance with surface electromyography. | The subject is standing with the dynamometer in his hand. He/she must press the dynamometer during one minute trying to maintain maximal force. | 24 hours after the intervention |
| Neural tension test (ROM) | The subject is lying on the stretcher. We make a neurodynamic test and when she/he experience tension in his/her arm, she/he must tell us "stop". We measure the range of motion of the elbow extension as the outcome | pre-intervention / baseline |
| Change in neural tension test (ROM) | The subject is lying on the stretcher. We make a neurodynamic test and when she/he experience tension in his/her arm, she/he must tell us "stop". We measure the range of motion of the elbow extension as the outcome | Immediately after the intervention |
| Change in neural tension test (ROM) | The subject is lying on the stretcher. We make a neurodynamic test and when she/he experience tension in his/her arm, she/he must tell us "stop". We measure the range of motion of the elbow extension as the outcome | 24 hours after the intervention |
| Change in arterial end-diastolic velocity with Color Doppler Ultrasonography | In the placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial end-diastolic velocity during 5 cardiac cycles. | Immediately after the needle insertion |
| Arterial time average mean velocity during cardiac cycle with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial time average mean velocity during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial time average mean velocity during cardiac cycle with Color Doppler Ultrasonography | In the placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial time average mean velocity during 5 cardiac cycles. | Immediately after the needle insertion |
| Arterial end-diastolic velocity with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial end-diastolic velocity during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial end-diastolic velocity with Color Doppler Ultrasonography | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial end-diastolic velocity during 5 cardiac cycles. | Immediately after the intervention |
| Change in arterial time average mean velocity during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial time average mean velocity during 5 cardiac cycles. | Immediately after the intervention |
| Arterial time average maximun velocity during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial time average maximun velocity during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial time average maximun velocity during cardiac cycle with Color Doppler | In placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial time average maximun velocity during 5 cardiac cycles. | Immediately after the needle insertion |
| Change in arterial time average maximun velocity during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial time average maximun velocity during 5 cardiac cycles. | Immediately after the intervention |
| Arterial pulsatility index during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial pulsatility index during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial pulsatility index during cardiac cycle with Color Doppler | In placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial pulsatility index during 5 cardiac cycles. | Immediately after the needle insertion |
| Change in arterial pulsatility index during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial pulsatility index during 5 cardiac cycles. | Immediately after the intervention |
| Arterial arterial resistivity index during cardiac cycle with Color Doppler | In placebo group, on the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial resistivity index during 5 cardiac cycles. | pre-intervention / baseline |
| Change in arterial resistivity index during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial resistivity index during 5 cardiac cycles. | Immediately after the needle insertion |
| Change in arterial resistivity index during cardiac cycle with Color Doppler | On the marked areas (Brachial ipsilateral and contralateral, radial and ulnar arteries) we measure the arterial resistivity index during 5 cardiac cycles. | Immediately after the intervention |
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