Comparison of Lidocaine-Prilocaine Combination and Vapocoolant for IV Cannulation Pain in the ED

Comparison of The Efficacy of Lidocaine-Prilocaine Combination and Vapocoolant Spray to Reduce Pain of IV Cannulation in The Emergency Department: A Randomized Clinical Trial

Hypothesis: Lidocaine-Prilocaine Combination is as effective as Vapocoolant in treating IV cannulation pain in the emergency department.

Lidocain-Prilocaine combination cream is two amide-type local anesthetics used for topical skin anesthesia. Vapocoolant spray is also another method for providing appropriate analgesia through crayoanesthetic mechanisms. Although there are some contraindications and adverse effects, these are widely used in the Emergency Department (ED) for IV cannulation pain.

Inclusion Criteria:

• Low acute patients who are waiting for the admission to the ED and require IV cannulation

Exclusion Criteria:

• Altered mental status
• Uncooperative patients
• Unable to communicate
• Known history of hypersensitivity reaction to cold or amid analgesics
• Analgesic usage in previous 6 hours
• No consent
• Emergent condition
• Pregnancy and lactation