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Hypothesis: Lidocaine-Prilocaine Combination is as effective as Vapocoolant in treating IV cannulation pain in the emergency department.
Lidocain-Prilocaine combination cream is two amide-type local anesthetics used for topical skin anesthesia. Vapocoolant spray is also another method for providing appropriate analgesia through crayoanesthetic mechanisms. Although there are some contraindications and adverse effects, these are widely used in the Emergency Department (ED) for IV cannulation pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vapocoolant spray | Active Comparator | Patients in this arm will receive vapocoolant spray before IV cannulation. |
|
| Lidocaine-Prilocaine cream | Active Comparator | Patients in this arm will receive Lidocaine-Prilocaine cream before IV cannulation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vapocoolant spray | Drug | The spray will be applied continuously from 25 cm distance for less than 5 seconds to the cannulation site. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cannulation pain: numerical rating score (NRS) | The numerical rating score (NRS) will be used for the study. The NRS ranges from 0 (no pain) to 10 (very severe pain). The higher the pain scores the higher the pain severity. The pain severity will be asked from the patients. | immediately after the procedure. |
| Measure | Description | Time Frame |
|---|---|---|
| Application pain: numerical rating score (NRS) | The numerical rating score (NRS) will be used for the study. The NRS ranges from 0 (no pain) to 10 (very severe pain). The higher the pain scores the higher the pain severity. The pain severity will be asked from the patients. | immediately after the procedure. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IKCH | Tehran | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40118519 | Derived | Akhgar A, Mazidabadi Farahani A, Akbari H, Sedaghat M, Jalili M, Mirfazaelian H. Comparison of the effects of vapocoolant spray and topical anaesthetic cream (lidocaine-prilocaine) on pain of intravenous cannulation: a randomised controlled trial. Emerg Med J. 2025 May 22;42(6):373-377. doi: 10.1136/emermed-2024-214479. |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Lidocaine-Prilocaine cream | Drug | A finger tip (0.5 gr) of the cream will be applied in 4 square cm at cannulation site and will be covered with closed dressing for 45 minutes. |
|
| Catheterization attempts |
Number of times the direction of IV catheter is changed before the successful cannulation. Exit from the skin is also considered an attempt. |
| immediately after the procedure. |