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A small cross-over trial on 3 different doses of liposomal vitamin C, comparing vitamin C uptake and downstream effects when 24 people consume 1, 2, and 5 grams on different test days, compared to placebo.
A randomized, cross-over study design will be used to evaluate the effects of consumption of 4 different doses of liposomal vitamin C (0, 1, 2, and 5 grams). The study is of 5 weeks' duration, with evaluation of a different dose at each of week 1, week 3 and week 5 with a one week washout between each dose.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liposomal vitamin C, 1 gram | Active Comparator | Participants will consume 1 gram on study day |
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| Liposomal vitamin C, 2 grams | Active Comparator | Participants will consume 2 grams on study day |
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| Liposomal vitamin C, 5 grams | Active Comparator | Participants will consume 5 grams on study day |
|
| Placebo | Placebo Comparator | Participants will consume placebo on study day |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liposomal vitamin C, 1 gram | Dietary Supplement | after a blood draw 1 gram of vitamin c will be consumed followed by 3 additional blood draws |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of vitamin C levels | HPLC (High performance liquid chromatography) | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of antioxidant status | FRAP (Ferric reducing antioxidant power) assay | 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of downstream effects reflecting antioxidant protection | lipid peroxidation | 6 hours |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gitte Jensen, PhD | Contact | 541-884-0112 | gitte@nislabs.com |
| Name | Affiliation | Role |
|---|---|---|
| Gitte Jensen, PhD | NIS Labs | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gitte Jensen | Recruiting | Klamath Falls | Oregon | 97601 | United States |
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Randomized, placebo-controlled, single blind, cross-over trial
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| Liposomal vitamin C, 2 grams | Dietary Supplement | after a blood draw 2 grams of vitamin c will be consumed followed by 3 additional blood draws |
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| Liposomal vitamin C, 5 grams | Dietary Supplement | after a blood draw 5 grams of vitamin c will be consumed followed by 3 additional blood draws |
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| Placebo | Dietary Supplement | after a blood draw placebo will be consumed followed by 3 additional blood draws |
|