Use HeprAN ™ membrane (coated with heparin) should be allow the success of dialysis sessions, with adequate dialysis parameters, in patients treated by long-term anticoagulation with VKA, without addition of heparin perdialytic.

Less use of heparin (UFH or LMWH) during hemodialysis session should be allow a decrease of bleedings (moderate or major) and blood transfusions for hemodialysed patients with HeprAN ™ membrane and treated by long-term anticoagulation with VKA

The aim will be to study possibility of hemodialysis sessions success, without perdialytic anticoagulation but with adequate dialysis parameters (defined by the patient's Kt / V machine), in patients treated by long-term anticoagulation with VKA and dialysed with the HeprAN ™ membrane.

inclusion criteria :

• 18 years old and older
• chronic hemodialysis for at least 3 months
• treated by long-term anticoagulation with VKA
• hemodialysis with the HeprAN® membrane
• per dialytic heparin therapy (UFH or LMWH)
• dialyzed at Reims University Hospital
• agreeing to participate in the study

Exclusion criteria

• chronic hemodialysis without per dialytic heparin
• Patient dialized with single lumen catheter for vascular access
• less than 18 years old
• pregnant or lactating women
• protected by law