Soluble ST2 and Cardiovascular Outcome

Association Between Soluble ST2 and Cardiovascular Outcome After Cardiovascular Surgery

Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant cardiovascular morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) is biomarker of myocardial remodeling and fibrosis; however, little is known regarding their potential association with cardiovascular events. This study aimed to investigate the release of sST2 and its association with cardiovascular events undergoing cardiac surgery.

Inclusion Criteria:

• age ≥ 18 years
• Congenital heart disease requiring surgery
• Valvular heart disease requiring surgery
• Arrhythmia requiring surgery
• Aortic dissection requiring surgery
• Coronary heart disease requiring surgery

Exclusion Criteria:

• age <18 years
• pregnancy
• severe renal dysfunction (creatinine >200µmol/L)
• not capable of understanding or signing informed consent.