The virus infection Covid-19 fills our hospitals and intensive care departments in a very unique way and there is a lack of essential insight into the pathophysiology of the disease. As a result, very specific treatment options are missing. The US Medicines Agency (FDA) has in the last days given a general license for treatment with inhaled nitric oxide (iNO). Inhaled NO in Sweden (and Europe) is approved for the indication of pulmonary hypertension in adults.

However, no one has yet described the occurrence of pulmonary hypertension, with or without right ventricular loading, in the Covid-19 patients who become so seriously ill that they need to be treated at an IVA ward. Knowledge of this is, of course, a prerequisite for determining the need for pulmonary artery catheterization (PA catheter, Swan-Ganz catheter) and also to better understand whether iNO treatment or other forms of lung selective vasodilation therapy may be of benefit to this patient group.

Demographics and data from study variables will be documented in paper CRFs at the investigational site.

• Demography

  o Age, sex

• Covid-19 related variables

  o COVID-19 diagnosis

• Concomitant diseases

  o Comorbidity, previous and present

• Cardiovascular risk factors

  o Smoking

• Laboratory values

• On-site measurements o Evaluation with echocardiography

Inclusion Criteria:

• Men and women at least 18 years of age
• Diagnosed with COVID-19 and is treated at an intensive care unit.

Exclusion Criteria:

• Responsible investigator considers that co-morbidity is so pronounced that it does not allow reasonable interpretation of data.
• Missing verified diagnosis of COVID-19

This is a non-interventional retrospective study to be performed in an intensive care unit in Sweden. The study will include 80 Covid-19 patients who had been examined with echocardiography. Data will be collected through chart review.

Individual participants data that underlie the results reported in this article will be shared, after deidentification (text, figures and appendices)

Beginning 3 months and ending 5 years following article publication.

Researchers who provide a methodologically sound proposal and to achieve aims in the proposal. Proposals should be directed to per-arne.lonnqvist@ki.se. To gain access, data requestors will need to sign a data access agreement.