MIKROBE Management of Infected Knee Replacements-Obtaining Best Evidence

MIKROBE Management of Infected Knee Replacements-Obtaining Best Evidence A Feasibility Study for a Randomised Controlled Trial of One-stage or Two-stage Surgery for Prosthetic Knee Infection

Following a prosthetic knee joint infection, two types of operative approach can be undertaken to treat the infection: a one-stage or two-stage revision operation. Both approaches are widely used and are good at treating infection but we don't know which has the best long-term outcomes for patients. This trial aims to assess the feasibility of conducting a randomised controlled trial to evaluate whether treating a prosthetic knee infection with one-stage revision surgery gives a better outcome than two-stage revision surgery in terms of patient function and pain, and cost-effectiveness.

Inclusion Criteria:

• Adults with prosthetic knee infection suitable for either one-stage or two-stage revision surgery
• Intra-operatively, all cases must have adequate soft-tissue coverage post debridement to allow single or two stage revision surgery.
• Case meets the International Consensus Meeting criteria for infection
• Patients having had a Debridement, Anti-biotic and Implant Retained procedure previously or washout/biopsy only of an infected TKR are suitable

Exclusion Criteria:

• Unable or unwilling to undergo either treatment
• Lacking capacity to consent to research
• Refusal to consent to study for any reason
• Re-revision of prosthetic knee infection if first revision was for infection
• Presence of tuberculosis infection