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| Name | Class |
|---|---|
| University of Aarhus | OTHER |
| Lundbeck Foundation | OTHER |
| Danish National Research Foundation | OTHER |
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Persistent pain may lead to several alterations in the brain activity and sensory perception (i.e. pain). Around 80% of professional musicians experience prolonged episodes of musculoskeletal pain throughout their careers, a percentage that is four times higher than in the general population. With this background, the intended experiment aims at understanding the role of several biological factors associated to sensorimotor training that can lead to alteration of the brain activity and, consequently, pain processing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy musicians | Men and women aged 18-60, who must be enrolled in a music conservatory performance program or be professionally active, and must speak and understand English. |
| |
| Healthy non-musicians | Men and women aged 18-60, must speak and understand English and not have any kind of musical training. |
| |
| Musicians with chronic pain | Men and women aged 18-60 with chronic and idiopathic musculoskeletal upper limb and/or neck pain lasting more than 6 months. They must be enrolled in a music conservatory performance program or be professionally active and must speak and understand English. |
| |
| Non-musicians with chronic pain | Men and women aged 18-60 with chronic and idiopathic musculoskeletal upper limb and/or neck pain lasting more than 6 months. They must not have any kind of musical training and must speak and understand English. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nerve Growth Factor | Drug | Induction of experimental muscle soreness using intramuscular injections of Nerve Growth Factor. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain rating | Pain on an 11-point numerical rating scale (0 = no pain, 10 = most intense pain imaginable) | Changes from baseline measured at day 3 and day 8 |
| Cortical Sensory Evoked Potentials | Electrical stimulation will be elicited to record sensory evoked potentials using electroencephalography (EEG) | Changes from baseline measured at day 3 and day 8 |
| Motor Evoked Potentials | Transcranial magnetic stimualtion will be used to evoke motor evoked potentials (MEPs) | Changes from baseline measured at day 3 and day 8 |
| Brain connectivity | Continuous electroencephalography recording will be used to explore connectivity between brain areas | Changes from baseline measured at day 3 and day 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Questionnaires | Questionnaires about pain and muscle soreness (Pain catastrophization; State and Trait anxiety; Pain vigilance) | Changes from baseline measured at day 3 and day 8 |
| Pressure pain thresholds |
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Inclusion Criteria:
Healthy men and women Speak and understand English.
General exclusion criteria are:
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Healthy men and women Speak and understand English.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg University | Aalborg | North Denmark | 9000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40728516 | Derived | Zamorano AM, Kleber B, De Martino E, Insausti-Delgado A, Vuust P, Flor H, Graven-Nielsen T. Prior use-dependent plasticity triggers different individual corticomotor responses during persistent musculoskeletal pain. Pain. 2025 Dec 1;166(12):e856-e863. doi: 10.1097/j.pain.0000000000003749. Epub 2025 Jul 30. |
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| ID | Term |
|---|---|
| D059352 | Musculoskeletal Pain |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D020932 | Nerve Growth Factor |
| ID | Term |
|---|---|
| D009414 | Nerve Growth Factors |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
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Pressure applied to the surface of the skin using a handheld algometer
| Changes from baseline measured at day 3 and day 8 |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011506 | Proteins |
| D009419 | Nerve Tissue Proteins |
| D001685 | Biological Factors |