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The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure. This study aimed to compare the Nesiritide induced hemodynamical status changes among congestive heart failure patients with invasive ventilation support.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nesiritide | Drug | The attending physicans decide whether to use Nesiritide for congestive heart failure patients. Only patients who will use Nesiritide are enrolled. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of cardiac output | Changes of cardiac output measured by hemodynamical monitoring tools | Before and 30-min after using a standard dose of Nesiritide |
| Changes of systemic filling pressure | Changes of the intercept of regression line of paired VR-RAP points at different PEEP levels. | Before and 30-min after using a standard dose of Nesiritide |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of cardiac function curve | Using body position changes (±15°) to simulate the change of preload, and therefore depicte the Starling curve | Before and 30-min after using a standard dose of Nesiritide |
| Changes of venous return curve |
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Inclusion Criteria:
Exclusion Criteria:
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Congestive heart failure patients relying on mechanical ventilation and therefore decide to try the Nesiritide.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhe Luo, MD | Contact | +8613916127028 | luo.zhe@zs-hospital.sh.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Hospital | Recruiting | Xuhui | Shanghai Municipality | 200032 | China |
Our institution did not approve this.
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D020097 | Natriuretic Peptide, Brain |
| ID | Term |
|---|---|
| D045265 | Natriuretic Peptides |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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Changes of venous return curve depicted by different PEEP setting
| Before and 30-min after using a standard dose of Nesiritide |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |