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Chilblains (inflammatory lesion of the feet or hands) have been reported with an unusual frequency during the confinement period, most commonly in children, teenagers and young adults. The aim of the ECCES study is to find out whether these manifestations of chilblains can be linked to the SARS-CoV-2 coronavirus.
For this, an epidemiologic study will compare two types of family (or more precisely people who were confined together in March-April-May):
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects with chilblains | Experimental |
| |
| Subjects without chilblains | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biological sample collection | Other | 10mL blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| Level of viral exposure in "case family" compared to "comparator family" | Through study completion, an average of 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of seropositivity rates in subjects with chilblains and their age-matched controls | Through study completion, an average of 3 months | |
| Comparison of SARS-CoV-2 seropositivity rates among members of case (subject with chilblains) and control (subject without chilblains) outbreaks |
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Inclusion Criteria:
Exclusion Criteria:
- Subject legally protected (under judicial protection, guardianship), persons deprived of liberty
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Angers | Angers | 49933 | France | |||
| CHRU Brest |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34515805 | Result | Poizeau F, Barbarot S, Le Corre Y, Brenaut E, Samimi M, Aubert H, Toubel A, Dupuy A. Long-term Outcome of Chilblains Associated with SARS-CoV-2. Acta Derm Venereol. 2021 Dec 13;101(12):adv00614. doi: 10.2340/00015555-3930. | |
| 34619397 | Result | Poizeau F, Oger E, Barbarot S, Le Corre Y, Samimi M, Brenaut E, Aubert H, Chambrelan E, Droitcourt C, Gissot V, Heslan C, Laurent C, Martin L, Misery L, Tattevin P, Toubel A, Thibault V, Dupuy A. Chilblains during lockdown are associated with household exposure to SARS-CoV-2: a multicentre case-control study. Clin Microbiol Infect. 2022 Feb;28(2):285-291. doi: 10.1016/j.cmi.2021.09.032. Epub 2021 Oct 4. |
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| ID | Term |
|---|---|
| D002647 | Chilblains |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D005627 | Frostbite |
| D000067390 | Cold Injury |
| D014947 | Wounds and Injuries |
| D011024 | Pneumonia, Viral |
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| Through study completion, an average of 3 months |
| Antibody avidity and differentiated IgG and IgM assay by subject in the homes | Through study completion, an average of 3 months |
| Brest |
| 29609 |
| France |
| CHU Nantes | Nantes | 44093 | France |
| CHU Rennes | Rennes | 35033 | France |
| CHRU Tours | Tours | 37170 | France |
| D011014 |
| Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |