Physiological Response to 5 Days Fasting

Physiological Response to Prolonged Fasting in Healthy Volunteers

To investigate energy metabolism, anthropometry, blood pressure, gut microbiome, serum metabolome, glucose variability and neural mechanisms of food choice and mood before and after 5 days of fasting as well as their persistence in healthy men and women.

Inclusion Criteria:

• Men and women
• 20-50 years
• Body mass index 20-30 kg/m2

Exclusion Criteria:

• Clinically relevant heart, lung, liver, and kidney diseases
• Any prescribed medication (except for oral contraceptives)
• Current or chronic infection
• Intake of antibiotics within 6 months before study entry
• Fasting week within 6 months before study entry
• Habitual use of dietary supplements
• Food intolerances
• Pregnancy, lactation
• Vegan diet
• Smokers
• In addition for fMRI: sensorineural hearing loss, tinnitus, metal implants, electric devices