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To investigate energy metabolism, anthropometry, blood pressure, gut microbiome, serum metabolome, glucose variability and neural mechanisms of food choice and mood before and after 5 days of fasting as well as their persistence in healthy men and women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fasting | Active Comparator | Starts immediately with 5 days of Buchinger fasting |
|
| Waiting list control | Placebo Comparator | Starts with 5 days of Buchinger fasting after a waiting period of 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Buchinger fasting | Other | Caloric intake of < 250 kcal/d for 5 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Resting Energy Expenditure | Measured by indirect calorimetry (kcal/d) | 6-th day of fasting compared to baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Resting Energy Expenditure - Recovery | Measured by indirect calorimetry (kcal/d) | 12 weeks after fasting compared to baseline |
| Resting Respiratory Exchange Ratio | Measured by indirect calorimetry |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sylvia Bähring, PhD | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité Universitätsmedizin Berlin | Berlin | 13125 | Germany |
Individual participant data that underlie the results of reported articles (text, tables, figures, supplemental data) will be shared after deidentification.
Beginning 9 months and ending 36 months following article publication.
Researchers who provide a methodologically sound proposal.
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Waiting list control group
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| 6-th day of fasting and 28 days after fasting compared to baseline |
| Office systolic blood pressure | Mean of five consecutive blood pressure measurements (mmHg) | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Office diastolic blood pressure | Mean of five consecutive blood pressure measurements (mmHg) | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Fecal microbiome composition | Measured by 16S Sequencing | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Fecal and serum metabolome | Measured by mass spectrometry | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Change in immune cell phenotypes | Peripheral blood effector T cell frequencies (Percent) | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Glucose variability | Measured by continuous glucose monitoring over 14 days | From 3 days before until 6 days after fasting |
| Neural correlates of emotion processing | Measured by functional Magnetic Resonance Imaging | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Neural correlates of food-specific delay discounting | Measured by functional Magnetic Resonance Imaging | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Perceived Stress Questionaire (PSQ) | Range 0-100, with 0 indicating no perceived stress | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| Perceived Self Efficiency | Range 10-40, with 40 indicating highest self efficiency | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| PANAS Positive Affect Subscale (GESIS Panel) | Range 10-50, with 50 indicating highest positive affect | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| PANAS Negative Affect Subscale (GESIS Panel) | Range 10-50, with 50 indicating highest negative affect | 6-th day of fasting and 12 weeks after fasting compared to baseline |
| International Physical Activity Questionaire (IPAQ, long version) | Time for moderate and vigorous activity (hours, minutes) | 6-th day of fasting and 12 weeks after fasting compared to baseline |