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Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks. The analysis of r-fMRI can be done thanks to the graph theory, which is based on the based on the calculation of quantifiable parameters applied to the functional network studied, making it possible to assess its effectiveness.
To the knowledge of the investigators, no study has used graph theory applied to r-fMRI data in order to obtain parameters useful for the useful parameters for the individual prognosis of children who have to be operation for drug-resistant lesional epilepsy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resting-state functional MRI (r-fMRI) | The MRI examination will be performed on a 3T multi-parametric MRI. Compared to the standard protocol, patients will benefit from an additional fMRI-r sequence, called resting state, and performed before injection of gadoline contrast. A neuropsychological evaluation is performed as part of the 6 months prior to the procedure. These data will be used as a basis for the evaluation of language visual and language recovery. |
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| Measure | Description | Time Frame |
|---|---|---|
| Determine the prognostic value of topological parameters measured on local r-fMRI on the surgical success at one year of patients operated for drug-resistant epilepsy. | The variables measured with functional MRI will correspond to topological parameters of functional connectivity measured locally at the level of the lesion: the degree, the clustering coefficient and path length. Surgical success will be evaluated by a score of 1 on the modified Engel classification at one year after surgery. | One year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from 6 to 18 years old receiving an MRI as part of a preoperative assessment of lesion epilepsy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sidney KRYSTAL | Contact | 01 48 03 65 65 | + 33 | skrystal@for.paris |
| Amelie YAVCHITZ | Contact | 01 48 03 65 65 | + 33 | ayavchitz@for.paris |
| Name | Affiliation | Role |
|---|---|---|
| Sidney KRYSTAL | Adolphe de Rothschild Fondation Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation A De Rothschild | Recruiting | Paris | PARIS | 75019 | France |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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