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This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF. Patient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond 3 days post-PD). The investigators compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.
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| Measure | Description | Time Frame |
|---|---|---|
| postoperative pancreatic fistula | fluid output of any measureable volume via an operatively placed drain with amylase activity greater than 3 times the upper normal serum value | through study completion, an average of 2 month |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative interventions | transarterial embolization, image-guided second drainage, and reoperation | through study completion, an average of 2 month |
| length of hospital stay | through study completion, an average of 2 month |
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Inclusion Criteria:
Exclusion Criteria:
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underwent PD in Chang Gung Memorial Hospital at Linkou
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| ID | Term |
|---|---|
| D010185 | Pancreatic Fistula |
| ID | Term |
|---|---|
| D016154 | Digestive System Fistula |
| D004066 | Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D005402 | Fistula |
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| 30-day mortality rates | 30 day |
| D020763 |
| Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |