This study aims to evaluate safety, tolerability and efficacy of a new treatment for upper limb motor rehabilitation after severe stroke using non-invasive neurotechnologies. The investigational system is used alone or coupled with brain stimulation provided by transcranic direct current stimulation.

This study aims at providing two interventions:

In the first intervention, a brain computer interface able to non-invasively detect motor intention from the non-invasive measure of brain activity by using electroencephalography (BrainVision, V-amp) activates a robotic glove (Gloreha Sinfonia, Idrogenet Srl) that will assist-as-needed hand movements and paretic upper limb functional electric stimulation (RehaStim, Hasomed). The latter will activate upper limb muscles to perform motor rehabilitation exercises for the upper limb. The motor rehabilitation exercises include upper limb and hand mobilization and functional tasks, such as hand open/closing, wrist flexion/extension, and reach and grasp a cup, keep and release.

In the second intervention, non-invasive brain stimulation (DC-Stimulator, NeuroConn) in the form of transcranial direct current stimulation will be provided in addition to the previous intervention.

Each participant will perform a minimum of 11 rehabilitative sessions for the first intervention and a minimum of 11 rehabilitative sessions for the second intervention, for a total minimum of 22 rehabilitative sessions. If the participant recovers with the intervention, the relative rehabilitative session continues to be proposed until patients will reaches a "plateau". The intervention will switch from 1 to 2 if the participant does not improve anymore with the 1st intervention. If the patient does not improve anymore with the 2nd intervention the interventional part of the trial will be finished. The intervention(s) will terminate also if the participant continues to progress after 6 months of inclusion. As the study is especially designed for personalization of intervention for every patient, it is not possible to determine a priori the number of sessions for each participant, because they depend on the response of each participant to the intervention. The duration of each rehabilitative visit is about two and half hours.

Inclusion Criteria:

• Chronic cerebral stroke patients (at least 6 months after the event).
• First ever clinical manifest stroke.
• No or minimal residual voluntary finger extension.
• Upper limb FM score < 20.
• Age > 18 years.
• Right or left severe hemiparesis.
• Ischemic or hemorrhagic stroke with intact hand knob area.

Exclusion Criteria:

• Patient with an active implantable device or wearing an active device.
• Occurrence of new clinically manifest stroke.
• Cerebellar stroke.
• Drug or alcohol dependency.
• Pregnancy.
• Refusal to perform any proposed pregnancy test for women in childbearing age (18 to menopausal age).
• Psychotic symptoms and significant psychopharmacologic treatments with neuroleptics and/or Lithium and antiepileptics
• Use of medication that significantly interacts with non-invasive brain stimulation being benzodiazepines, tricyclic antidepressant and antipsychotics.
• Severe spasticity that prevent the patient to use the robotic orthosis (indicative Modified Ashworth Scale > 3).
• Severe cognitive problems and severe neglect.
• Physical features impeding the recording of brain signals or the muscular signals stimulation (voluminous hair and large amount of subcutaneous fat in the arms).
• Severe heart disease.
• Allergy to latex and dermatitis.
• Epileptic seizures or using medications that reduce the threshold for epileptic seizures.
• Travel distance to the study site more than 70 Km.
• Involvement in other clinical treatment trials related to stroke.
• Participant does not want to be informed about the potential fortuitous discoveries that may contribute to the prevention, diagnosis and treatment of existing or probable diseases in the future.