Intrauterine Antibiotic Infusion in Treating Chronic Endometritis and Restoring Reproductive Dynamics

Introducing Intrauterine Antibiotic Infusion as a Novel Approach in Effectively Treating Chronic Endometritis and Restoring Reproductive Dynamics: A Pilot Study

Chronic Endometritis (CE) is related to infertility and entails a challenging management. This study investigates the treatment of off-label intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration (OAA), and it assesses respective performance against the gold standard treatment of OAA. Data sourced herein reports on treatment efficiency and fertility restoration for both patients aiming to conceive naturally or via In Vitro fertilization (IVF).

Inclusion Criteria:

• Positive diagnosis of CE
• Recurrent Pregnancy Loss (RPL) or Recurrent Implantation Failure (RIF)
• No previous live birth
• FSH and LH levels -evaluated on day 2 of the menstrual cycle- <12 IU/ml
• AMH levels >1.1ng/ml
• Progesterone levels -evaluated on day 21 of the menstrual cycle- > 2 and <25 ng/ml
• 18.5<BMI<29.9
• 18<Patients' age<40

Exclusion Criteria:

• Diagnosed endometriosis or other related Pelvic Inflammatory Disorder (PID)
• Current or previous cancer diagnosis
• Auto-immune, genetic or reproductive disorders
• Reproductive history of pregnancy loss due to genetic abnormalities
• Male factor infertility diagnosis