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Subarachnoid block is a widely used anesthetic technique for cesarean section. To improve the quality of analgesia and prolong its duration, the addition of intrathecal opioids to local anesthetics has been encouraged.
In a double blind randomized controlled trial, 60 parturient women ASA 2-3 scheduled for elective cesarean delivery under spinal anesthesia will be randomly divided into 2 groups: Group 1 will receive sufentanil 5 μg and Group 2 will receive meperidine 12.5 mg. In every group, 0.5% heavy bupivacaine 10 will be added.
A questionnaire will be used to collect data. Patients' demographic and operative characteristics will be recorded. These include block level, heart rate, mean arterial pressure, nausea, vomiting, shivering and use of vasopressors. Post-operative data include pain, analgesic consumption, nausea and vomiting, as well as patients and surgeons satisfaction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sufentanil Group | Experimental | Patients will receive sufentanil 5 μg in addition to 0.5% heavy bupivacaine spinal anesthesia |
|
| Meperidine Group | Experimental | Patients will receive meperidine 12.5 mg in addition to 0.5% heavy bupivacaine spinal anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sufentanil | Drug | Patients will receive sufentanil in spinal anesthesia |
| |
| Measure | Description | Time Frame |
|---|---|---|
| First analgesic request time | The duration of effective analgesia is defined as the time from intrathecal injection to first patient analgesic demand | 24 hours post operatively |
| Measure | Description | Time Frame |
|---|---|---|
| Analgesic requirements | A questionnaire will be used to record the analgesics consumed by the patients | 24 hours post operatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Saleh Kanawati, MD | Contact | +9611636000 | 6405 | s.kanawati@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Saleh Kanawati, MD | Makassed General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Makassed General Hospital | Recruiting | Beirut | Lebanon |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35083557 | Derived | Kanawati S, Barada MA, Naja Z, Rajab O, Sinno L, El Hasan J. Comparison of clinical effects of meperidine and sufentanil added to 0.5% hyperbaric bupivacaine for spinal anesthesia in patients undergoing cesarean delivery: a randomized controlled trial. J Anesth. 2022 Apr;36(2):201-209. doi: 10.1007/s00540-021-03031-6. Epub 2022 Jan 27. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D017409 | Sufentanil |
| D008614 | Meperidine |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| meperidine |
| Drug |
Patients will receive meperidine in spinal anesthesia |
|
| Bupivacaine | Drug | Patients will receive 0.5% heavy bupivacaine in spinal anesthesia |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007540 |
| Isonipecotic Acids |
| D000147 | Acids, Heterocyclic |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |