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| Name | Class |
|---|---|
| Friedrich-Alexander-Universität Erlangen-Nürnberg | OTHER |
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Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort.
The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIT-resistance exercise | High Intensity Resistance Exercise | ||
| Non exercising control | Control group that maintained life style and physical activity habits |
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| Measure | Description | Time Frame |
|---|---|---|
| SMI | Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry | Change from Baseline to 26 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| BMD-LS | Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry | Change from Baseline to 26 weeks |
| BMD-hip | Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry |
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Inclusion Criteria:
Exclusion Criteria:
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Participants of the FrOST study (men 72 years and older with osteosarcopenia)
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| Name | Affiliation | Role |
|---|---|---|
| wolfgang Kemmler, PhD | Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Medical Physics, Friedrich Alexander University Erlangen-Nürnberg | Erlangen | Bavaria | 91052 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32270891 | Background | Kemmler W, Kohl M, Frohlich M, Jakob F, Engelke K, von Stengel S, Schoene D. Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia-One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). J Bone Miner Res. 2020 Sep;35(9):1634-1644. doi: 10.1002/jbmr.4027. Epub 2020 Apr 28. | |
| 31908428 |
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The data that support the findings of this study are available from the corresponding author, [WK], upon reasonable request.
no limitation
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| Change from Baseline to 26 weeks |
| Sarcopenia-Z-Score | Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity) | Change from Baseline to 26 weeks |
| Fat infiltration thigh muscles | Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging | Change from Baseline to 26 weeks |
| Fat infiltration para-vertebral muscles | Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging | Change from Baseline to 26 weeks |
| Maximum hip-/leg extensor strength | Maximum hip-/leg extensor strength as determined by an isokinetic leg press | Change from Baseline to 26 weeks |
| Metabolic Syndrome Z-Score | Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure) | Change from Baseline to 26 weeks |
| Self rated physical performance | Late-Life Function and Disability Index of McAuley et al. | Change from Baseline to 26 weeks |
| Background |
| Lichtenberg T, von Stengel S, Sieber C, Kemmler W. The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study. Clin Interv Aging. 2019 Dec 16;14:2173-2186. doi: 10.2147/CIA.S225618. eCollection 2019. |
| 33249320 | Derived | Kemmler W, Kohl M, Frohlich M, Schoene D, von Stengel S. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone. 2021 Jan;142:115772. doi: 10.1016/j.bone.2020.115772. Epub 2020 Nov 26. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |