The purpose of this study is to evaluate the safety, tolerability, drug levels and drug effects of single and multiple oral doses of BMS-986331 versus placebo in healthy participants and healthy Japanese participants.

Inclusion Criteria:

• No clinically significant deviations in medical history, physical examination, ECGs, vital signs, and clinical laboratory determinations
• A body mass index of 18 - 32 kg/m2, inclusive
• Women and men must agree to follow specific methods of contraception, if applicable

For J-MAD Part 3

• Must be Japanese (both biological parents are ethnically Japanese)

Exclusion Criteria:

• Women who are of childbearing potential
• Women who are pregnant or breastfeeding
• Any significant acute or chronic medical illness
• Current or recent (within 3 months of study drug administration) gastrointestinal disease that could impact upon the absorption of study drug
• Any surgery within 12 weeks of study drug administration

Other protocol-defined inclusion/exclusion criteria apply