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The aim of this study is to evaluate analgesic effects Bupivacaine, Bupivacaine plus Dexmedetomidine and Bupivacaine plus Fentanyl in relieving pain after knee arthroscopic surgery.
Forty-five patients ASA I - II aged 21-45 years for elective knee arthroscopy were divided into 3 groups: Group B, BD and BF. Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).
Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug). The time of first request of analgesia and analgesic effect by VAS during the first 24 hr. postoperatively are recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group B | Active Comparator | IGroup B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline |
|
| group BD | Active Comparator | . Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug). |
|
| group BF | Active Comparator | Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of postoperative analgesia | start from intra-articular injection of the drug to the time of first request of analgesia | For 24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| total dose of rescue analgesia ( pethidine) | total consumption of rescue analgesia (pethidine) postoperative | within 24 hours postoperative |
| The number of participants with bradycardia, itching and hypotension |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dina Salem, MD. | faculty of medicine , Zagazig University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zagazig university | Zagazig | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34704709 | Derived | Salem DAE, Nabi SMA, Alagamy SA, Kamel AAF. Comparative Study Between Dexmedetomidine and Fentanyl as an Adjuvant to Intraarticular Bupivacaine for Postoperative Analgesia after Knee Arthroscopy. Pain Physician. 2021 Nov;24(7):E989-E996. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D005283 | Fentanyl |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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analgesia for postoperative pain after knee arthroscopy: dexmedetomidine+bupivacaine, fentanyl+bupivacaine , bupivacaine
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anesthetist not sharing in the study will assess patient
| Fentanyl | Drug | Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug) |
|
| Bupivacain | Drug | Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline. |
|
|
The number of participants with bradycardia less than 50 beat per minute, itching and hypotension if mean arterial blood pressure less than 20% of basal )
| Within 24 hours postoperative |
| patient satisfaction | Patient satisfaction by five point Likert-Like verbal rating scale by asking the patient how they evaluate the experience with the analgesic management after the the surgery? (5-very satisfied, 4-satisfied, 3-neutral, 2-dissatisfied, 1-very dissatisfied) | within 24 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale (0- no pain and 10-the worst pain) | measured immediately preoperative 0 minute ( admission receiving area) |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 30 minutes postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 1 hour postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 2 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 4 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 6 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 8 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 12 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 18 hours postoperative |
| pain intensity at rest (static) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 24 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | measured immediately preoperative 0 minute ( admission receiving area) |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 30 minutes postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 1 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 2 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 4 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 6 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 8 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 12 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 18 hours postoperative |
| pain intensity on mobilization of operated knee (dynamic) | measured by VAS on 0-10 cm scale(0- no pain and 10-the worst pain) | at 24 hours postoperative |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010880 |
| Piperidines |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |