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Sleepiness is frequent in parkinsonian patients, increasing with the duration of disease. By patients with motor fluctuations, continuous dopaminergic delivery devices or deep brain stimulation are justified to improve the motor prognosis. Antiparkinsonian treatments, especially dopaminergic agonists, may worsen the sleepiness and thus affect the quality of life. The investigators aimed to monitor sleepiness in parkinsonian patients before and during treatment with continous dopaminergic delivery device or deep brain stimulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| continuous apomorphine delivery | apomorphine, subcutaneous administration, continuous delivery during 8 to 24 hours/day |
| |
| continous levodopa/carbidopa delivery | levodopa/carbidopa monohydrate, jejunal administration, continuous delivery during 8 to 24 hours/day |
| |
| deep brain stimulation | bilateral subthalamic electrical stimulation, intracranial neurosurgical electrodes, individual electrical parameters settings |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multiple sleep latency tests | Diagnostic Test | The investigators measure the objective sleepiness by recording the electro-encephalogramm during four experimental diurnal naps. They also perform a nocturnal polysomnography prior to the tests for a better interpretation. |
| Measure | Description | Time Frame |
|---|---|---|
| Mean sleep latency | Algebric mean (in minutes) of the sleep latency for the four experimental naps | before continuous antiparkinsonian treatment |
| Mean sleep latency | Algebric mean (in minutes) of the sleep latency for the four experimental naps | 6 months after continuous antiparkinsonian treatment |
| Mean sleep latency | Algebric mean (in minutes) of the sleep latency for the four experimental naps | 12 months after continous antiparkinsonian treatment |
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Inclusion Criteria:
Exclusion Criteria:
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All the patients refered to the expert Parkinson Center of the Nancy University Hospital, with the diagnosis of Parkinson's disease at the stage of motor fluctuations, and indicated for a continuous dopaminergic delivery device or deep brain stimulation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nicolas Carpentier | Contact | 0033383858585 | n.carpentier@chru-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| El Mehdi Siaghy | Research and Innovation Department | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nancy University Hospital | Recruiting | Nancy | 54000 | France |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D000077260 | Sleepiness |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D017286 | Polysomnography |
| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |