Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ketorolac Intraarticular Hip Injection | Experimental | Patients will receive an intraarticular hip injection with ketorolac. |
|
| Triamcinolone Intraarticular Hip Injection | Active Comparator | Patients will receive an intraarticular hip injection with triamcinolone. |
|
| Ketorolac Intraarticular Knee Injection | Experimental | Patients will receive an intraarticular knee injection with ketorolac. |
|
| Triamcinolone Intraarticular Knee Injection | Active Comparator | Patients will receive an intraarticular knee injection with triamcinolone. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketorolac Intraarticular Injection | Drug | Injections will be given under ultrasound guidance with one of two possible medications. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Visual Analogue Scale (Baseline to One Week Post-injection) | Pain Score | Comparing baseline to one week post-injection |
| Change in Visual Analogue Scale (Baseline to One Month Post-injection) | Pain Score | Comparing baseline to one month post-injection |
| Change in Visual Analogue Scale (Baseline to Three Months Post-injection) | Pain Score | Comparing baseline to three months post-injection |
| Change in PROMIS Global Health Scores (Baseline to One Week Post-injection) | Overall patient wellbeing | Comparing baseline to one week post-injection |
| Change in PROMIS Global Health Scores (Baseline to One Month Post-injection) | Overall patient wellbeing | Comparing baseline to one month post-injection |
| Change in PROMIS Global Health Scores (Baseline to Three Months Post-injection) | Overall patient wellbeing | Comparing baseline to three months post-injection |
| Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Week Post-injection) | Functionality and pain of affected knee | Comparing baseline to one week post-injection |
| Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Month Post-injection) |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Kevin Jurgensmeier, BS | Student Investigator at Saint Alphonsus Regional Medical Center | Principal Investigator |
| Steven B Daines, MD | Surgeon at Saint Alphonsus Regional Medical Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32950343 | Derived | Jurgensmeier K, Jurgensmeier D, Kunz DE, Fuerst PG, Warth LC, Daines SB. Intra-articular Injections of the Hip and Knee With Triamcinolone vs Ketorolac: A Randomized Controlled Trial. J Arthroplasty. 2021 Feb;36(2):416-422. doi: 10.1016/j.arth.2020.08.036. Epub 2020 Aug 22. |
Not provided
Not provided
No plan currently decided.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Triamcinolone Intraarticular Injection | Drug | Injections will be given under ultrasound guidance with one of two possible medications. |
|
Functionality and pain of affected knee |
| Comparing baseline to one month post-injection |
| Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to Three Months Post-injection) | Functionality and pain of affected knee | Comparing baseline to three months post-injection |
| Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Week Post-injection) | Functionality and pain of affected hip | Comparing baseline to one week post-injection |
| Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Month Post-injection) | Functionality and pain of affected hip | Comparing baseline to one month post-injection |
| Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to Three Months Post-injection) | Functionality and pain of affected hip | Comparing baseline to three months post-injection |