Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Inclusion Criteria:

• Symptomatic, radiographically proven degenerative joint disease in the hip or knee

Exclusion Criteria:

• recent injection in the hip or knee within the previous 3 months
• history of traumatic osteoarthritis or ligamentous reconstruction
• chronic narcotic use
• history of inflammatory or neuropathic arthropathy
• pregnant and/or nursing women
• allergy or strong reaction to study medications