Relationship Between Endoplasmic Reticulum Stress and Pain in Patients With Endometriosis

Endoplasmic Reticulum Stress and Endometriosis Releated Pain

The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.

Women between the ages of 18-50 who were diagnosed with endometriosis by surgery and ultrasound, without known rheumatological or metabolic diseases were included in the study. Most of the patients are composed of newly diagnosed patients.

Inclusion Criteria:

• diagnosed endometriosis with ultrasound or surgery
• no metabolic diseases
• no rheumatological diseases

Exclusion Criteria:

• Immune modulator, hormonal, anti-inflammatory use history in the last 3 months