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This study seeks to determine how COVID-19 affects the clinical outcome of patients with chronic liver disease, and whether the clinical course of COVID-19 is influenced by underlying chronic liver disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic Liver Disease Group | COVID-19 patients with Chronic Liver Disease. |
| |
| Control Group | COVID-19 patients without Chronic Liver Disease. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prospective Chart Review | Other | Collected data will include demographic features, clinical characteristics, clinical outcome, medication use, COVID-19-related complications in patients with chronic liver disease. |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | Death due to any cause | 30 days |
| All-cause mortality | Death due to any cause | 1 year |
| Liver-related mortality | Death due to liver-related cause | 28 days |
| Liver-related mortality | Death due to liver-related cause | 1 year |
| Overall survival | Patients will be assessed for this outcome for up to 1 year | Up to 1 year |
| Number of patients with hepatic decompensation | Onset of hepatic decompensation due to COVID-19 disease; patients will be assessed for this outcome for up to 1 year | Up to 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients requiring hospitalization | Patients will be assessed for this outcome for up to 1 year. | Up to 1 year |
| Duration of hospitalization | Patients will be assessed for this outcome for up to 1 year. |
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Inclusion Criteria:
Confirmed diagnosis of COVID-19
Personal history of either
Exclusion Criteria:
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Patients with chronic liver disease with a confirmed diagnosis of COVID-19
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| Name | Affiliation | Role |
|---|---|---|
| Renumathy Dhanasekaran, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arizona, | Phoenix | Arizona | 85004 | United States | ||
| Mayo Clinic |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32950749 | Result | Kim D, Adeniji N, Latt N, Kumar S, Bloom PP, Aby ES, Perumalswami P, Roytman M, Li M, Vogel AS, Catana AM, Wegermann K, Carr RM, Aloman C, Chen VL, Rabiee A, Sadowski B, Nguyen V, Dunn W, Chavin KD, Zhou K, Lizaola-Mayo B, Moghe A, Debes J, Lee TH, Branch AD, Viveiros K, Chan W, Chascsa DM, Kwo P, Dhanasekaran R. Predictors of Outcomes of COVID-19 in Patients With Chronic Liver Disease: US Multi-center Study. Clin Gastroenterol Hepatol. 2021 Jul;19(7):1469-1479.e19. doi: 10.1016/j.cgh.2020.09.027. Epub 2020 Sep 17. | |
| 32964510 |
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| Up to 1 year |
| Length of intensive care unit (ICU) stay | Patients will be assessed for this outcome for up to 1 year. | Up to 1 year |
| Number of participants requiring mechanical ventilation | Patients will be assessed for this outcome for up to 1 year. | Up to 1 year |
| Scottsdale |
| Arizona |
| 85259 |
| United States |
| UCSF Fresno | Fresno | California | 93701 | United States |
| University of Southern California | Los Angeles | California | 90007 | United States |
| Stanford University | Stanford | California | 94305 | United States |
| Georgetown University | Washington D.C. | District of Columbia | 20057 | United States |
| VA Medical Center | Washington D.C. | District of Columbia | 20422 | United States |
| University of Miami | Miami | Florida | 33136 | United States |
| Rush University Medical Center | Chicago | Illinois | 60612 | United States |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
| Oschner Medical Center | Baton Rouge | Louisiana | 70816 | United States |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | United States |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | United States |
| University of Michigan | Ann Arbor | Michigan | 48109 | United States |
| Hennepin County Medical Center (HCMC) | Minneapolis | Minnesota | 55415 | United States |
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
| Mount Sinai School of Medicine | New York | New York | 10029 | United States |
| Weill Cornell Medicine | New York | New York | 10065 | United States |
| Duke University | Durham | North Carolina | 27710 | United States |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | United States |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | United States |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | United States |
| Result |
| Rabiee A, Sadowski B, Adeniji N, Perumalswami PV, Nguyen V, Moghe A, Latt NL, Kumar S, Aloman C, Catana AM, Bloom PP, Chavin KD, Carr RM, Dunn W, Chen VL, Aby ES, Debes JD, Dhanasekaran R; COLD Consortium. Liver Injury in Liver Transplant Recipients With Coronavirus Disease 2019 (COVID-19): U.S. Multicenter Experience. Hepatology. 2020 Dec;72(6):1900-1911. doi: 10.1002/hep.31574. Epub 2020 Dec 9. |
| 33227281 | Result | Adeniji N, Carr RM, Aby ES, Catana AM, Wegermann K, Dhanasekaran R. Socioeconomic Factors Contribute to the Higher Risk of COVID-19 in Racial and Ethnic Minorities With Chronic Liver Diseases. Gastroenterology. 2021 Mar;160(4):1406-1409.e3. doi: 10.1053/j.gastro.2020.11.035. Epub 2020 Nov 20. No abstract available. |
| 33713486 | Result | Efe C, Dhanasekaran R, Lammert C, Ebik B, Higuera-de la Tijera F, Aloman C, Riza Caliskan A, Peralta M, Gerussi A, Massoumi H, Catana AM, Torgutalp M, Purnak T, Rigamonti C, Gomez Aldana AJ, Khakoo N, Kacmaz H, Nazal L, Frager S, Demir N, Irak K, Ellik ZM, Balaban Y, Atay K, Eren F, Cristoferi L, Batibay E, Urzua A, Snijders R, Kiyici M, Akyildiz M, Ekin N, Carr RM, Harputluoglu M, Hatemi I, Mendizabal M, Silva M, Idilman R, Silveira M, Drenth JPH, Assis DN, Bjornsson E, Boyer JL, Invernizzi P, Levy C, Schiano TD, Ridruejo E, Wahlin S. Outcome of COVID-19 in Patients With Autoimmune Hepatitis: An International Multicenter Study. Hepatology. 2021 Jun;73(6):2099-2109. doi: 10.1002/hep.31797. |
| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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